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Crat carnitine acetyltransferase [ Mus musculus (house mouse) ]

Gene ID: 12908, updated on 26-Sep-2022

Summary

Official Symbol
Cratprovided by MGI
Official Full Name
carnitine acetyltransferaseprovided by MGI
Primary source
MGI:MGI:109501
See related
Ensembl:ENSMUSG00000026853 AllianceGenome:MGI:109501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CARAT
Summary
Predicted to enable acyl-CoA oxidase activity and carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked and fatty acid metabolic process. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 140.8), heart adult (RPKM 116.2) and 20 other tissues See more
Orthologs
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Genomic context

See Crat in Genome Data Viewer
Location:
2 B; 2 21.69 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30290488..30306029, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30400476..30416017, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene mitoguardin 2 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene protein phosphatase 2 protein activator Neighboring gene immediate early response 5-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables carnitine O-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carnitine O-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables carnitine O-octanoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carnitine O-acetyltransferase
Names
CAT
carnitine acetylase
NP_031786.2
XP_006497708.1
XP_006497709.1
XP_006497710.1
XP_030102925.1
XP_030102928.1
XP_030102929.1
XP_030102930.1
XP_030102931.1
XP_030102932.1
XP_036013843.1
XP_036013845.1
XP_036013849.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007760.3NP_031786.2  carnitine O-acetyltransferase

    See identical proteins and their annotated locations for NP_031786.2

    Status: VALIDATED

    Source sequence(s)
    AK041431, AK132179, AL954299
    Consensus CDS
    CCDS15882.1
    UniProtKB/Swiss-Prot
    P47934, Q923A6
    Related
    ENSMUSP00000028207.7, ENSMUST00000028207.13
    Conserved Domains (1) summary
    pfam00755
    Location:35615
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30290488..30306029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247068.1XP_030102928.1  carnitine O-acetyltransferase isoform X5

    UniProtKB/TrEMBL
    H7BX88
    Conserved Domains (1) summary
    pfam00755
    Location:14594
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  2. XM_006497645.4XP_006497708.1  carnitine O-acetyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00755
    Location:35620
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  3. XM_030247069.1XP_030102929.1  carnitine O-acetyltransferase isoform X5

    UniProtKB/TrEMBL
    H7BX88
    Conserved Domains (1) summary
    pfam00755
    Location:14594
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  4. XM_006497647.2XP_006497710.1  carnitine O-acetyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006497710.1

    Conserved Domains (1) summary
    pfam00755
    Location:14599
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  5. XM_030247070.1XP_030102930.1  carnitine O-acetyltransferase isoform X5

    UniProtKB/TrEMBL
    H7BX88
    Related
    ENSMUSP00000099918.4, ENSMUST00000102854.10
    Conserved Domains (1) summary
    pfam00755
    Location:14594
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  6. XM_030247071.1XP_030102931.1  carnitine O-acetyltransferase isoform X6

    Conserved Domains (1) summary
    pfam00755
    Location:23545
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  7. XM_030247065.1XP_030102925.1  carnitine O-acetyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00755
    Location:35615
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  8. XM_036157952.1XP_036013845.1  carnitine O-acetyltransferase isoform X5

    UniProtKB/TrEMBL
    H7BX88
    Conserved Domains (1) summary
    pfam00755
    Location:14594
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  9. XM_036157950.1XP_036013843.1  carnitine O-acetyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00755
    Location:14599
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  10. XM_036157956.1XP_036013849.1  carnitine O-acetyltransferase isoform X7

    Conserved Domains (1) summary
    pfam00755
    Location:23540
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  11. XM_030247072.2XP_030102932.1  carnitine O-acetyltransferase isoform X6

    Conserved Domains (1) summary
    pfam00755
    Location:23545
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  12. XM_006497646.5XP_006497709.1  carnitine O-acetyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00755
    Location:35620
    Carn_acyltransf; Choline/Carnitine o-acyltransferase