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Cpt1a carnitine palmitoyltransferase 1a, liver [ Mus musculus (house mouse) ]

Gene ID: 12894, updated on 21-Mar-2023

Summary

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Official Symbol
Cpt1aprovided by MGI
Official Full Name
carnitine palmitoyltransferase 1a, liverprovided by MGI
Primary source
MGI:MGI:1098296
See related
Ensembl:ENSMUSG00000024900 AllianceGenome:MGI:1098296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPTI; Cpt1; C730027G07
Summary
Enables carnitine O-palmitoyltransferase activity and palmitoleoyltransferase activity. Predicted to be involved in several processes, including carnitine metabolic process; positive regulation of fatty acid beta-oxidation; and regulation of insulin secretion. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; sensory organ; and urinary system. Used to study carnitine palmitoyltransferase I deficiency. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 56.8), adrenal adult (RPKM 53.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cpt1a in Genome Data Viewer
Location:
19 A; 19 3.08 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3372328..3435735)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3322326..3385735)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene microRNA 6984 Neighboring gene testis expressed metallothionein like Neighboring gene galanin and GMAP prepropeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension. Lee MH, et al. Am J Physiol Lung Cell Mol Physiol, 2022 Sep 1. PMID 35763400,
  2. Carnitine palmitoyltransferase 1A is essential for decidualization in mice. Li N, et al. Theriogenology, 2022 Jan 15. PMID 34837783
  3. CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair. Yuan Q, et al. Cell Death Dis, 2021 Aug 14. PMID 34392303, Free PMC Article
  4. Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation. Hao F, et al. Proc Natl Acad Sci U S A, 2021 Jun 1. PMID 34035164, Free PMC Article
  5. Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis. Miguel V, et al. J Clin Invest, 2021 Mar 1. PMID 33465052, Free PMC Article

See all (117) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes.
    Title: miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes.
  2. CPT1alpha maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair.
    Title: CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair.
  3. Carnitine palmitoyltransferase 1A is essential for decidualization in mice.
    Title: Carnitine palmitoyltransferase 1A is essential for decidualization in mice.
  4. Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation.
    Title: Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation.
  5. Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis.
    Title: Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis.
  6. Upregulation of CPT1A is essential for the tumor-promoting effect of adipocytes in colon cancer.
    Title: Upregulation of CPT1A is essential for the tumor-promoting effect of adipocytes in colon cancer.
  7. CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis.
    Title: CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis.
  8. findings indicate that downregulation of carnitine palmitoyltransferase 1a by lipid content modulates macrophage phagocytosis and inflammatory phenotype
    Title: CPT1a gene expression reverses the inflammatory and anti-phagocytic effect of 7-ketocholesterol in RAW264.7 macrophages.
  9. CPT gene upregulation increased mitochondrial reactive oxygen species (ROS) and led to cell apoptosis.
    Title: Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4(+) T cell apoptosis promoting HCC development.
  10. Diet-induced hepatic steatosis activates Ras to promote hepatocarcinogenesis via CPT1alpha pathway.
    Title: Diet-induced hepatic steatosis activates Ras to promote hepatocarcinogenesis via CPT1α.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables carnitine O-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carnitine O-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables palmitoleoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carnitine O-palmitoyltransferase 1, liver isoform
Names
CPT I
CPT1-L
CPTI-L
L-CPT I
carnitine palmitoyltransferase 1, liver
NP_038523.2
XP_006531717.1
XP_006531721.1
XP_006531722.1
XP_011246904.1
XP_036017309.1
XP_036017310.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013495.2 → NP_038523.2  carnitine O-palmitoyltransferase 1, liver isoform

    See identical proteins and their annotated locations for NP_038523.2

    Status: VALIDATED

    Source sequence(s)
    AK147770, BC054791, CJ081259
    Consensus CDS
    CCDS29395.1
    UniProtKB/Swiss-Prot
    P97742, Q8C7H8
    UniProtKB/TrEMBL
    Q3UGT1, Q7TQD5
    Related
    ENSMUSP00000025835.5, ENSMUST00000025835.6
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    3372328..3435735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248602.4 → XP_011246904.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X2

    Conserved Domains (2) summary
    pfam16484
    Location:26 → 71
    CPT_N; Carnitine O-palmitoyltransferase N-terminus
    pfam00755
    Location:196 → 786
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  2. XM_036161416.1 → XP_036017309.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

    UniProtKB/Swiss-Prot
    Q8C7H8
    UniProtKB/TrEMBL
    Q7TQD5
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  3. XM_006531654.4 → XP_006531717.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

    See identical proteins and their annotated locations for XP_006531717.1

    UniProtKB/Swiss-Prot
    P97742, Q8C7H8
    UniProtKB/TrEMBL
    Q7TQD5
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  4. XM_006531659.2 → XP_006531722.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

    See identical proteins and their annotated locations for XP_006531722.1

    UniProtKB/Swiss-Prot
    P97742, Q8C7H8
    UniProtKB/TrEMBL
    Q7TQD5
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  5. XM_036161417.1 → XP_036017310.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X3

    Conserved Domains (2) summary
    pfam00755
    Location:171 → 628
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  6. XM_006531658.5 → XP_006531721.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

    See identical proteins and their annotated locations for XP_006531721.1

    UniProtKB/Swiss-Prot
    P97742, Q8C7H8
    UniProtKB/TrEMBL
    Q7TQD5
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97742.4 GenPept UniProtKB/Swiss-Prot:P97742

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