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FAM83C family with sequence similarity 83 member C [ Homo sapiens (human) ]

Gene ID: 128876, updated on 23-Nov-2021

Summary

Official Symbol
FAM83Cprovided by HGNC
Official Full Name
family with sequence similarity 83 member Cprovided by HGNC
Primary source
HGNC:HGNC:16121
See related
Ensembl:ENSG00000125998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf128; dJ614O4.7
Summary
This gene encodes a member of the family with sequence similarity 83 protein family. The encoded protein may be involved in regulating MAPK signaling in cancer cells. [provided by RefSeq, Mar 2017]
Expression
Biased expression in skin (RPKM 18.2) and esophagus (RPKM 10.6) See more
Orthologs
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Genomic context

See FAM83C in Genome Data Viewer
Location:
20q11.22
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (35285731..35292425, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33873534..33880228, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene MMP24-AS1-EDEM2 readthrough Neighboring gene matrix metallopeptidase 24 Neighboring gene FAM83C antisense RNA 1 Neighboring gene MMP24 opposite strand Neighboring gene Sharpr-MPRA regulatory region 10216 Neighboring gene eukaryotic translation initiation factor 6 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene Sharpr-MPRA regulatory region 14546

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053068.1 RefSeqGene

    Range
    4998..11692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178468.6NP_848563.1  protein FAM83C

    See identical proteins and their annotated locations for NP_848563.1

    Status: REVIEWED

    Source sequence(s)
    AK091116, AL121753, BC113483
    Consensus CDS
    CCDS13251.1
    UniProtKB/Swiss-Prot
    Q9BQN1
    Related
    ENSP00000363529.3, ENST00000374408.4
    Conserved Domains (1) summary
    cd09183
    Location:34304
    PLDc_FAM83C_N; N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83C

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    35285731..35292425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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