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BPIFA3 BPI fold containing family A member 3 [ Homo sapiens (human) ]

Gene ID: 128861, updated on 13-May-2022

Summary

Official Symbol
BPIFA3provided by HGNC
Official Full Name
BPI fold containing family A member 3provided by HGNC
Primary source
HGNC:HGNC:16204
See related
Ensembl:ENSG00000131059 AllianceGenome:HGNC:16204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPLUNC3; C20orf71
Summary
Predicted to enable lipid binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 31.7) See more
Orthologs
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Genomic context

See BPIFA3 in Genome Data Viewer
Location:
20q11.21
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (33217310..33227806)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34944548..34955045)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31805116..31815612)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 2 pseudogene 1 Neighboring gene BPI fold containing family A member 4, pseudogene Neighboring gene uncharacterized LOC105372593 Neighboring gene BPI fold containing family A member 1 Neighboring gene ribosomal protein L12 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC44525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BPI fold-containing family A member 3
Names
short long palate, lung and nasal epithelium carcinoma associated 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042439.2NP_001035904.1  BPI fold-containing family A member 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001035904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AI638623, AL121901, BC066354
    Consensus CDS
    CCDS42865.1
    UniProtKB/Swiss-Prot
    Q9BQP9
    Related
    ENSP00000364601.3, ENST00000375452.3
    Conserved Domains (1) summary
    cl00188
    Location:98183
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
  2. NM_178466.5NP_848561.2  BPI fold-containing family A member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848561.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AI638623, BC066354, BF966133, HY050111
    Consensus CDS
    CCDS13216.2
    UniProtKB/Swiss-Prot
    Q9BQP9
    Related
    ENSP00000364603.3, ENST00000375454.8
    Conserved Domains (1) summary
    cl00188
    Location:48219
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    33217310..33227806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_244132.4 RNA Sequence

    Related
    ENST00000471233.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34944548..34955045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)