U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BPIFB6 BPI fold containing family B member 6 [ Homo sapiens (human) ]

Gene ID: 128859, updated on 3-May-2025
Official Symbol
BPIFB6provided by HGNC
Official Full Name
BPI fold containing family B member 6provided by HGNC
Primary source
HGNC:HGNC:16504
See related
Ensembl:ENSG00000167104 MIM:614110; AllianceGenome:HGNC:16504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPIL3; LPLUNC6
Summary
Predicted to enable lipid binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, May 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See BPIFB6 in Genome Data Viewer
Location:
20q11.21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (33031648..33044108)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34758339..34770799)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31619454..31631853)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sad1 and UNC84 domain containing 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31588518-31589018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31589019-31589519 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31594895-31595890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31595891-31596885 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:31601764-31602328 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:31602329-31602894 Neighboring gene BPI fold containing family B member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31605961-31606556 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31629439-31629940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31640995-31641529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31641530-31642063 Neighboring gene pseudouridine 5'-phosphatase pseudogene 3 Neighboring gene BPI fold containing family B member 3

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
BPI fold-containing family B member 6
Names
bactericidal/permeability-increasing protein-like 3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174897.2NP_777557.1  BPI fold-containing family B member 6 precursor

    See identical proteins and their annotated locations for NP_777557.1

    Status: VALIDATED

    Source sequence(s)
    AF465767, BC113122
    Consensus CDS
    CCDS13211.1
    UniProtKB/Swiss-Prot
    Q8NFQ5
    Related
    ENSP00000344929.1, ENST00000349552.1
    Conserved Domains (2) summary
    cd00025
    Location:21227
    BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
    cl00188
    Location:274448
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    33031648..33044108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027663.1XP_016883152.1  BPI fold-containing family B member 6 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34758339..34770799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322980.1XP_054178955.1  BPI fold-containing family B member 6 isoform X1