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BPIFB6 BPI fold containing family B member 6 [ Homo sapiens (human) ]

Gene ID: 128859, updated on 5-Jan-2022

Summary

Official Symbol
BPIFB6provided by HGNC
Official Full Name
BPI fold containing family B member 6provided by HGNC
Primary source
HGNC:HGNC:16504
See related
Ensembl:ENSG00000167104 MIM:614110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPIL3; LPLUNC6
Summary
Predicted to enable lipid binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See BPIFB6 in Genome Data Viewer
Location:
20q11.21
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (33031648..33044108)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31619454..31631853)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sad1 and UNC84 domain containing 5 Neighboring gene BPI fold containing family B member 2 Neighboring gene pseudouridine 5'-phosphatase pseudogene 3 Neighboring gene BPI fold containing family B member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BPI fold-containing family B member 6
Names
bactericidal/permeability-increasing protein-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174897.2NP_777557.1  BPI fold-containing family B member 6 precursor

    See identical proteins and their annotated locations for NP_777557.1

    Status: VALIDATED

    Source sequence(s)
    AF465767, BC113122
    Consensus CDS
    CCDS13211.1
    UniProtKB/Swiss-Prot
    Q8NFQ5
    Related
    ENSP00000344929.1, ENST00000349552.1
    Conserved Domains (2) summary
    cd00025
    Location:21227
    BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
    cl00188
    Location:274448
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    33031648..33044108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027663.1XP_016883152.1  BPI fold-containing family B member 6 isoform X1

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