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DUSP15 dual specificity phosphatase 15 [ Homo sapiens (human) ]

Gene ID: 128853, updated on 24-Nov-2020

Summary

Official Symbol
DUSP15provided by HGNC
Official Full Name
dual specificity phosphatase 15provided by HGNC
Primary source
HGNC:HGNC:16236
See related
Ensembl:ENSG00000149599 MIM:616776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VHY; C20orf57
Summary
The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Biased expression in testis (RPKM 10.5), kidney (RPKM 3.2) and 1 other tissue See more
Orthologs

Genomic context

See DUSP15 in Genome Data Viewer
Location:
20q11.21
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (31845578..31870664, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30435441..30458479, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TPX2 microtubule nucleation factor Neighboring gene myosin light chain kinase 2 Neighboring gene forkhead box S1 Neighboring gene tubulin tyrosine ligase like 9 Neighboring gene Sharpr-MPRA regulatory region 918 Neighboring gene RNA, U1 small nuclear 94, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20645, FLJ40111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 15
Names
VH1-related member Y
dual specificity phosphatase-like 15
vaccinia virus VH1-related dual-specific protein phosphatase Y
NP_001012662.1
NP_001307407.1
NP_001307408.1
NP_542178.2
NP_817130.1
XP_016883143.1
XP_016883144.1
XP_016883145.1
XP_016883146.1
XP_016883147.1
XP_016883148.1
XP_016883149.1
XP_016883150.1
XP_016883151.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012644.3NP_001012662.1  dual specificity protein phosphatase 15 isoform b

    See identical proteins and their annotated locations for NP_001012662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to isoform a. Variants 2 and 3 both encode isoform b, which has a shorter N-terminus than isoform a.
    Source sequence(s)
    AI051640, AK091960, AL732169, BC056911, BF377396, DN996690
    Consensus CDS
    CCDS42862.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000381157.1, ENST00000398083.5
    Conserved Domains (1) summary
    cl21483
    Location:135
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001320478.1NP_001307407.1  dual specificity protein phosphatase 15 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (c) has a distinct, shorter N-terminus than isoform a.
    Source sequence(s)
    AI051640, AK091960, AK097430, BM554314
    Consensus CDS
    CCDS82607.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000365133.4, ENST00000375966.8
    Conserved Domains (1) summary
    cd00127
    Location:1135
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  3. NM_001320479.1NP_001307408.1  dual specificity protein phosphatase 15 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains multiple differences at both the 5' and 3' ends, compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (d) has distinct N- and C-termini and is longer than isoform a.
    Source sequence(s)
    AK000652, AK097430
    Consensus CDS
    CCDS82606.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000278979.3, ENST00000278979.7
    Conserved Domains (2) summary
    cd00127
    Location:1135
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam10401
    Location:213246
    IRF-3; Interferon-regulatory factor 3
  4. NM_080611.5NP_542178.2  dual specificity protein phosphatase 15 isoform a

    See identical proteins and their annotated locations for NP_542178.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AL160175
    Consensus CDS
    CCDS13193.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000341658.5, ENST00000339738.9
    Conserved Domains (1) summary
    cd00127
    Location:4138
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  5. NM_177991.3NP_817130.1  dual specificity protein phosphatase 15 isoform b

    See identical proteins and their annotated locations for NP_817130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to isoform a. Variants 2 and 3 both encode isoform b, which has a shorter N-terminus than isoform a.
    Source sequence(s)
    AI051640, AK091960, BI517878, DN996690
    Consensus CDS
    CCDS42862.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000381158.2, ENST00000398084.6
    Conserved Domains (1) summary
    cl21483
    Location:135
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    31845578..31870664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027656.1XP_016883145.1  dual specificity protein phosphatase 15 isoform X3

  2. XM_017027660.1XP_016883149.1  dual specificity protein phosphatase 15 isoform X5

  3. XM_017027658.1XP_016883147.1  dual specificity protein phosphatase 15 isoform X5

  4. XM_017027659.1XP_016883148.1  dual specificity protein phosphatase 15 isoform X5

  5. XM_017027662.1XP_016883151.1  dual specificity protein phosphatase 15 isoform X5

  6. XM_017027661.1XP_016883150.1  dual specificity protein phosphatase 15 isoform X5

  7. XM_017027655.1XP_016883144.1  dual specificity protein phosphatase 15 isoform X2

  8. XM_017027657.1XP_016883146.1  dual specificity protein phosphatase 15 isoform X4

  9. XM_017027654.1XP_016883143.1  dual specificity protein phosphatase 15 isoform X1

RNA

  1. XR_001754159.1 RNA Sequence

  2. XR_001754160.1 RNA Sequence

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