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Cp ceruloplasmin [ Mus musculus (house mouse) ]

Gene ID: 12870, updated on 9-Mar-2023

Summary

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Official Symbol
Cpprovided by MGI
Official Full Name
ceruloplasminprovided by MGI
Primary source
MGI:MGI:88476
See related
Ensembl:ENSMUSG00000003617 AllianceGenome:MGI:88476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D3Ertd555e
Summary
The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression
Biased expression in liver adult (RPKM 26.7), liver E18 (RPKM 23.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3; 3 A2
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (20011097..20063914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19956933..20009750)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17771 Neighboring gene predicted gene, 42190 Neighboring gene HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene helicase-like transcription factor Neighboring gene VISTA enhancer mm86 Neighboring gene glycogenin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Schwann Cells Provide Iron to Axonal Mitochondria and Its Role in Nerve Regeneration. Mietto BS, et al. J Neurosci, 2021 Aug 25. PMID 34272312, Free PMC Article
  2. Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia. Ryan F, et al. Front Neurosci, 2018. PMID 30670944, Free PMC Article
  3. Ceruloplasmin replacement therapy ameliorates neurological symptoms in a preclinical model of aceruloplasminemia. Zanardi A, et al. EMBO Mol Med, 2018 Jan. PMID 29183916, Free PMC Article
  4. Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson's disease. You LH, et al. Neuroscience, 2015 Jan 22. PMID 25301748
  5. Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution. Gresle MM, et al. J Neurosci Res, 2014 Jun. PMID 24615902

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Placental Ferroxidase Zyklopen Is Not Essential for Iron Transport to the Fetus in Mice.
    Title: The Placental Ferroxidase Zyklopen Is Not Essential for Iron Transport to the Fetus in Mice.
  2. This study concluded that even when the ferroportin expression is high, ceruloplasmin remains a limiting factor in the release of iron to the extracellular environment.
    Title: Functional iron deficiency in toxic milk mutant mice (tx-J) despite high hepatic ferroportin: a critical role of decreased GPI-ceruloplasmin expression in liver macrophages.
  3. HEPH and CP are not essential for intestinal iron absorption but are required for proper systemic iron distribution.
    Title: Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.
  4. results suggest that ablation of hephaestin and ceruloplasmin could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions
    Title: Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.
  5. Ceruloplasmin regulates reelin processing, cofilin phosphorylation and neuronal organization in the developing brain.
    Title: The ferroxidase ceruloplasmin influences Reelin processing, cofilin phosphorylation and neuronal organization in the developing brain.
  6. Results show that both HEPH and CP are expressed in subcutaneous adipose tissue. Ablation of either MCF leads to a compensatory increase in the other, which contributes to the balance of iron status. However, ablation of both induces severe iron deposition in adipocytes and displays disordered carbohydrate metabolism characterized as type 2 diabetes.
    Title: Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.
  7. We thus used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout mice and Heph/Cp double-knockout mice to investigate the roles of multicopper ferroxidases(MCF) in pancreatic iron homeostasis. We found that both HEPH and CP were expressed in the mouse pancreas, and that ablation of either MCF had limited effect on the pancreatic iron levels.
    Title: Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.
  8. Hephaestin and ceruloplasmin have roles in facilitating iron metabolism in the mouse kidney
    Title: Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.
  9. In D-galactosamine-sensitized mice CP+Cu(II) increased the LPS-induced lethality from 54 to 100%, while administration of antibodies against MIF prevented the lethal effect. The enhancement by CP+Cu(II) of the pro-inflammatory signal of MIF is discussed
    Title: Interaction of macrophage migration inhibitory factor with ceruloplasmin: role of labile copper ions.
  10. mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels. Both neurons and glia degenerate and mice become ataxic unless given an iron chelator.
    Title: Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (2)  1 citation
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
enables ferroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within copper ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to copper ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
ceruloplasmin
Names
ferroxidase
NP_001263177.1
NP_001263179.1
NP_001361606.1
NP_031778.2
XP_006535444.1
XP_011247957.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276248.2 → NP_001263177.1  ceruloplasmin isoform c precursor

    See identical proteins and their annotated locations for NP_001263177.1

    Status: REVIEWED

    Source sequence(s)
    AC079442
    Consensus CDS
    CCDS71227.1
    UniProtKB/Swiss-Prot
    Q61147
    UniProtKB/TrEMBL
    G3X8Q5, Q8BU82
    Related
    ENSMUSP00000103964.2, ENSMUST00000108328.8
    Conserved Domains (5) summary
    cd04224
    Location:369 → 566
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:726 → 896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213 → 353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569 → 712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22 → 201
    Cupredoxin; Cupredoxin superfamily

  2. NM_001276250.2 → NP_001263179.1  ceruloplasmin isoform c precursor

    See identical proteins and their annotated locations for NP_001263179.1

    Status: REVIEWED

    Source sequence(s)
    AC079442
    Consensus CDS
    CCDS71227.1
    UniProtKB/TrEMBL
    G3X8Q5
    Related
    ENSMUSP00000003714.7, ENSMUST00000003714.13
    Conserved Domains (5) summary
    cd04224
    Location:369 → 566
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:726 → 896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213 → 353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569 → 712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22 → 201
    Cupredoxin; Cupredoxin superfamily

  3. NM_001374677.1 → NP_001361606.1  ceruloplasmin isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
    Consensus CDS
    CCDS89616.1
    UniProtKB/TrEMBL
    G3X9T8
    Related
    ENSMUSP00000103961.3, ENSMUST00000108325.9
    Conserved Domains (5) summary
    cd04224
    Location:369 → 566
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:726 → 896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213 → 353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569 → 712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22 → 201
    Cupredoxin; Cupredoxin superfamily

  4. NM_001409646.1 → NP_001396575.1  ceruloplasmin isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
    UniProtKB/TrEMBL
    E9PZD8

  5. NM_001409647.1 → NP_001396576.1  ceruloplasmin isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
    UniProtKB/TrEMBL
    E9PZD8

  6. NM_001409648.1 → NP_001396577.1  ceruloplasmin isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442

  7. NM_001409649.1 → NP_001396578.1  ceruloplasmin isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442

  8. NM_001409650.1 → NP_001396579.1  ceruloplasmin isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442

  9. NM_001409651.1 → NP_001396580.1  ceruloplasmin isoform h precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442

  10. NM_007752.4 → NP_031778.2  ceruloplasmin isoform b precursor

    See identical proteins and their annotated locations for NP_031778.2

    Status: REVIEWED

    Source sequence(s)
    AC079442
    Consensus CDS
    CCDS38401.1
    UniProtKB/Swiss-Prot
    Q61147, Q6P5C8
    Related
    ENSMUSP00000088857.6, ENSMUST00000091309.12
    Conserved Domains (5) summary
    cd04224
    Location:369 → 567
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:727 → 897
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213 → 353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:570 → 713
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22 → 201
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    20011097..20063914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535381.4 → XP_006535444.1  ceruloplasmin isoform X1

    UniProtKB/TrEMBL
    E9PZD8
    Conserved Domains (5) summary
    cd04224
    Location:369 → 567
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:727 → 897
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213 → 353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:570 → 713
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22 → 201
    Cupredoxin; Cupredoxin superfamily

  2. XM_011249655.4 → XP_011247957.1  ceruloplasmin isoform X1

    UniProtKB/TrEMBL
    E9PZD8
    Related
    ENSMUSP00000103965.2, ENSMUST00000108329.8
    Conserved Domains (5) summary
    cd04224
    Location:369 → 567
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:727 → 897
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213 → 353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:570 → 713
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22 → 201
    Cupredoxin; Cupredoxin superfamily

RNA

  1. XR_004941272.1 RNA Sequence

  2. XR_004941273.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042611.1: Suppressed sequence

    Description
    NM_001042611.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61147.2 GenPept UniProtKB/Swiss-Prot:Q61147

Gene LinkOut

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