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PROKR2 prokineticin receptor 2 [ Homo sapiens (human) ]

Gene ID: 128674, updated on 23-Nov-2021

Summary

Official Symbol
PROKR2provided by HGNC
Official Full Name
prokineticin receptor 2provided by HGNC
Primary source
HGNC:HGNC:15836
See related
Ensembl:ENSG00000101292 MIM:607123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3
Summary
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See PROKR2 in Genome Data Viewer
Location:
20p12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (5298852..5316954, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5279864..5297600, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene meiotic recombination hotspot R Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 1 Neighboring gene RNA, 5.8S ribosomal pseudogene 7 Neighboring gene long intergenic non-protein coding RNA 658

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prokineticin receptor 2
Names
G protein-coupled receptor 73-like 1
G-protein coupled receptor I5E
PK-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008132.2 RefSeqGene

    Range
    2638..18170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144773.4NP_658986.1  prokineticin receptor 2

    See identical proteins and their annotated locations for NP_658986.1

    Status: REVIEWED

    Source sequence(s)
    AL121755, AL121757
    Consensus CDS
    CCDS13089.1
    UniProtKB/Swiss-Prot
    Q8NFJ6
    UniProtKB/TrEMBL
    A8K1T0
    Related
    ENSP00000504128.1, ENST00000678254.1
    Conserved Domains (1) summary
    cd15204
    Location:54344
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    5298852..5316954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027646.1XP_016883135.1  prokineticin receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8NFJ6
    Conserved Domains (1) summary
    cd15204
    Location:54344
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
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