Cox7c cytochrome c oxidase subunit 7C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cox7cprovided by MGI
Official Full Name: cytochrome c oxidase subunit 7Cprovided by MGI
Primary source: MGI:MGI:103226
See related: Ensembl:ENSMUSG00000017778 AllianceGenome:MGI:103226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cox7c1; COXVIIc
Summary: Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human COX7C (cytochrome c oxidase subunit 7C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 584.6), kidney adult (RPKM 436.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13; 13 C3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (86192917..86194914, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (86044798..86046795, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-transport of the nuclear-encoded Cox7c mRNA with mitochondria along axons occurs through a coding-region-dependent mechanism.
Title: Co-transport of the nuclear-encoded Cox7c mRNA with mitochondria along axons occurs through a coding-region-dependent mechanism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136231 (e-PCR)
- UniSTS:210225

AI648091 (e-PCR)
- UniSTS:180565

RH126976 (e-PCR)
- UniSTS:167108

Homology

Homologs of the Cox7c gene: The Cox7c gene is conserved in Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 460 organisms have orthologs with human gene Cox7c
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
part_of mitochondrial respiratory chain complex IV	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: cytochrome c oxidase subunit 7C, mitochondrial

Names: cytochrome c oxidase polypeptide VIIc; cytochrome c oxidase subunit VIIc

NP_031775.1

EC 7.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007749.3 → NP_031775.1 cytochrome c oxidase subunit 7C, mitochondrial precursor

See identical proteins and their annotated locations for NP_031775.1

Status: VALIDATED

Source sequence(s)

AK131871, AV056265, BB696274

Consensus CDS

CCDS26668.1

UniProtKB/Swiss-Prot

P17665, Q3U5S7

UniProtKB/TrEMBL

A0A6P5QZK4, A0A8C6N2U4

Related

ENSMUSP00000115419.2, ENSMUST00000131011.2

Conserved Domains (1) summary

cd00929
Location:17 → 62

Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...