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TSHZ2 teashirt zinc finger homeobox 2 [ Homo sapiens (human) ]

Gene ID: 128553, updated on 2-Oct-2018

Summary

Official Symbol
TSHZ2provided by HGNC
Official Full Name
teashirt zinc finger homeobox 2provided by HGNC
Primary source
HGNC:HGNC:13010
See related
Ensembl:ENSG00000182463 MIM:614118; Vega:OTTHUMG00000033058
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSH2; ZABC2; ZNF218; OVC10-2; C20orf17
Summary
This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in gall bladder (RPKM 3.9), ovary (RPKM 3.7) and 23 other tissues See more
Orthologs

Genomic context

See TSHZ2 in Genome Data Viewer
Location:
20q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (52972309..53495330)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (51588946..52111869)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372666 Neighboring gene uncharacterized LOC105376985 Neighboring gene uncharacterized LOC105372668 Neighboring gene ribosomal protein L36 pseudogene 1 Neighboring gene RNA, 7SK small nuclear pseudogene 184 Neighboring gene uncharacterized LOC105372669 Neighboring gene uncharacterized LOC105372671 Neighboring gene peptidylprolyl isomerase A pseudogene 10 Neighboring gene uncharacterized LOC101927770 Neighboring gene zinc finger protein 217

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
NHGRI GWA Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33887, DKFZp686K2480

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
teashirt homolog 2
Names
cell growth-inhibiting protein 7
ovarian cancer-related protein 10-2
serologically defined colon cancer antigen 33 like
teashirt family zinc finger 2
zinc finger protein 218

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053184.1 RefSeqGene

    Range
    5099..528022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193421.1NP_001180350.1  teashirt homolog 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK302570, AL354993, AL391097, BQ574274, BX276189
    Consensus CDS
    CCDS54474.1
    UniProtKB/Swiss-Prot
    Q9NRE2
    Related
    ENSP00000475114.1, OTTHUMP00000165926, ENST00000603338.2, OTTHUMT00000259177
    Conserved Domains (2) summary
    cd00086
    Location:839907
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:214236
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_173485.5NP_775756.3  teashirt homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_775756.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL354993, BQ574274, BX276189, BX640770
    Consensus CDS
    CCDS33490.1
    UniProtKB/Swiss-Prot
    Q9NRE2
    Related
    ENSP00000360552.3, OTTHUMP00000031714, ENST00000371497.9, OTTHUMT00000080398
    Conserved Domains (2) summary
    cd00086
    Location:842910
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:217239
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    52972309..53495330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027641.1XP_016883130.1  teashirt homolog 2 isoform X2

  2. XM_017027640.1XP_016883129.1  teashirt homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NRE2
    Conserved Domains (2) summary
    cd00086
    Location:842910
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:217239
    ZF_C2H2; C2H2 Zn finger [structural motif]
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