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OCSTAMP osteoclast stimulatory transmembrane protein [ Homo sapiens (human) ]

Gene ID: 128506, updated on 24-Nov-2020

Summary

Official Symbol
OCSTAMPprovided by HGNC
Official Full Name
osteoclast stimulatory transmembrane proteinprovided by HGNC
Primary source
HGNC:HGNC:16116
See related
Ensembl:ENSG00000149635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OC-STAMP; C20orf123; dJ257E24.3
Summary
The protein encoded by this gene is orthologous to the mouse osteoclast stimulatory transmembrane protein (OCSTAMP), which is a membrane-anchored cell surface receptor that promotes nucleation of osteoclasts. The mouse protein is also involved in bone resorption and osteoclast differentiation. [provided by RefSeq, Feb 2017]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See OCSTAMP in Genome Data Viewer
Location:
20q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (46540946..46550654, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45169670..45179213, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene makorin ring finger protein 7, pseudogene Neighboring gene zinc finger protein 334 Neighboring gene zinc finger protein 840, pseudogene Neighboring gene solute carrier family 13 member 3 Neighboring gene TP53 regulating kinase Neighboring gene solute carrier family 2 member 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to estrogen stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
multinuclear osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of macrophage fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoclast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
osteoclast stimulatory transmembrane protein
Names
transmembrane protein C20orf123

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080721.3NP_542452.1  osteoclast stimulatory transmembrane protein

    See identical proteins and their annotated locations for NP_542452.1

    Status: REVIEWED

    Source sequence(s)
    AL034424
    Consensus CDS
    CCDS54468.1
    UniProtKB/Swiss-Prot
    Q9BR26
    Related
    ENSP00000279028.2, ENST00000279028.3
    Conserved Domains (1) summary
    pfam07782
    Location:254446
    DC_STAMP; DC-STAMP-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    46540946..46550654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528532.3XP_011526834.2  osteoclast stimulatory transmembrane protein isoform X1

    Conserved Domains (1) summary
    pfam07782
    Location:248440
    DC_STAMP; DC-STAMP-like protein
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