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Coq7 demethyl-Q 7 [ Mus musculus (house mouse) ]

Gene ID: 12850, updated on 5-Aug-2022

Summary

Official Symbol
Coq7provided by MGI
Official Full Name
demethyl-Q 7provided by MGI
Primary source
MGI:MGI:107207
See related
Ensembl:ENSMUSG00000030652 AllianceGenome:MGI:107207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
clk-1
Summary
Predicted to enable 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity and chromatin binding activity. Acts upstream of or within several processes, including age-dependent response to oxidative stress; chordate embryonic development; and mitochondrion morphogenesis. Located in mitochondrion. Is expressed in several structures, including alimentary system; ear; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 8. Orthologous to human COQ7 (coenzyme Q7, hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 25.4), CNS E11.5 (RPKM 15.8) and 28 other tissues See more
Orthologs
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Genomic context

See Coq7 in Genome Data Viewer
Location:
7 F1; 7 63.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118108882..118132579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118509659..118533356, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (125668576..125676827, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein-like 2 Neighboring gene predicted gene, 51516 Neighboring gene transmembrane channel-like gene family 7 Neighboring gene RIKEN cDNA B230311B06 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-demethoxyubiquinol 3-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of reactive oxygen species metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within respiratory electron transport chain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquinone biosynthetic process IC
Inferred by Curator
more info
PubMed 
NOT acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5-demethoxyubiquinone hydroxylase, mitochondrial
Names
DMQ hydroxylase
coenzyme Q biosynthesis protein 7 homolog
timing protein clk-1 homolog
ubiquinone biosynthesis monooxygenase COQ7
ubiquinone biosynthesis protein COQ7 homolog
NP_001291687.1
NP_034070.1
XP_030097920.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304758.1NP_001291687.1  5-demethoxyubiquinone hydroxylase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001291687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate exons including an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK158380, BY284216
    Consensus CDS
    CCDS80794.1
    UniProtKB/TrEMBL
    Q3TYT1
    Related
    ENSMUSP00000095695.4, ENSMUST00000098090.10
    Conserved Domains (1) summary
    pfam03232
    Location:49191
    COQ7; Ubiquinone biosynthesis protein COQ7
  2. NM_009940.3NP_034070.1  5-demethoxyubiquinone hydroxylase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_034070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC038681, BY284216
    Consensus CDS
    CCDS21771.1
    UniProtKB/Swiss-Prot
    P97478, Q9R0D7
    Related
    ENSMUSP00000032887.4, ENSMUST00000032887.4
    Conserved Domains (1) summary
    pfam03232
    Location:49216
    COQ7; Ubiquinone biosynthesis protein COQ7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    118108882..118132579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242060.1XP_030097920.1  5-demethoxyubiquinone hydroxylase, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam03232
    Location:11178
    COQ7; Ubiquinone biosynthesis protein COQ7