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NKAIN4 sodium/potassium transporting ATPase interacting 4 [ Homo sapiens (human) ]

Gene ID: 128414, updated on 7-Jun-2020

Summary

Official Symbol
NKAIN4provided by HGNC
Official Full Name
sodium/potassium transporting ATPase interacting 4provided by HGNC
Primary source
HGNC:HGNC:16191
See related
Ensembl:ENSG00000101198 MIM:612873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM77A; C20orf58; bA261N11.2
Summary
NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Expression
Biased expression in brain (RPKM 15.5), kidney (RPKM 2.4) and 1 other tissue See more
Orthologs

Genomic context

See NKAIN4 in Genome Data Viewer
Location:
20q13.33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63240780..63256406, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61872136..61885892, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene YTH N6-methyladenosine RNA binding protein 1 Neighboring gene microRNA 3196 Neighboring gene baculoviral IAP repeat containing 7 Neighboring gene uncharacterized LOC100192386 Neighboring gene ADP ribosylation factor GTPase activating protein 1 Neighboring gene microRNA 4326 Neighboring gene collagen type XX alpha 1 chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
Names
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4
Na+/K+ transporting ATPase interacting 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363718.1NP_001350647.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK126246, AL121827, BI918324, BJ991175, BM673598, HY107676
    Consensus CDS
    CCDS86967.1
    Related
    ENSP00000359336.1, ENST00000370313.5
    Conserved Domains (1) summary
    pfam05640
    Location:1115
    NKAIN; Na,K-Atpase Interacting protein
  2. NM_001363747.1NP_001350676.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK126246, AL121827, BM673598, BP219020, HY107676
    Consensus CDS
    CCDS86968.1
    Related
    ENSP00000359330.2, ENST00000370307.6
    Conserved Domains (1) summary
    pfam05640
    Location:1144
    NKAIN; Na,K-Atpase Interacting protein
  3. NM_152864.4NP_690603.3  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_690603.3

    Status: VALIDATED

    Source sequence(s)
    AK126246, BG708360, BM673598
    Consensus CDS
    CCDS13514.1
    UniProtKB/Swiss-Prot
    Q8IVV8
    UniProtKB/TrEMBL
    B3KWY5
    Related
    ENSP00000359340.3, ENST00000370316.8
    Conserved Domains (1) summary
    pfam05640
    Location:10206
    NKAIN; Na,K-Atpase Interacting protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63240780..63256406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027636.2XP_016883125.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    Conserved Domains (1) summary
    pfam05640
    Location:1143
    NKAIN; Na,K-Atpase Interacting protein
  2. XM_005260192.2XP_005260249.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X2

    See identical proteins and their annotated locations for XP_005260249.1

    Conserved Domains (1) summary
    pfam05640
    Location:10177
    NKAIN; Na,K-Atpase Interacting protein
  3. XM_011528527.2XP_011526829.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

    Conserved Domains (1) summary
    pfam05640
    Location:10205
    NKAIN; Na,K-Atpase Interacting protein
  4. XM_024451825.1XP_024307593.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X4

    Conserved Domains (1) summary
    pfam05640
    Location:1144
    NKAIN; Na,K-Atpase Interacting protein
  5. XM_011528529.3XP_011526831.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011526831.1

    Conserved Domains (1) summary
    pfam05640
    Location:1143
    NKAIN; Na,K-Atpase Interacting protein
  6. XM_017027637.2XP_016883126.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    Conserved Domains (1) summary
    pfam05640
    Location:1143
    NKAIN; Na,K-Atpase Interacting protein
  7. XM_011528528.3XP_011526830.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011526830.1

    Conserved Domains (1) summary
    pfam05640
    Location:1143
    NKAIN; Na,K-Atpase Interacting protein
  8. XM_017027639.2XP_016883128.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X4

    UniProtKB/TrEMBL
    A6NNM2
    Conserved Domains (1) summary
    pfam05640
    Location:1144
    NKAIN; Na,K-Atpase Interacting protein
  9. XM_024451824.1XP_024307592.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    Conserved Domains (1) summary
    pfam05640
    Location:1143
    NKAIN; Na,K-Atpase Interacting protein
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