U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MRPL55 mitochondrial ribosomal protein L55 [ Homo sapiens (human) ]

Gene ID: 128308, updated on 22-Sep-2022

Summary

Official Symbol
MRPL55provided by HGNC
Official Full Name
mitochondrial ribosomal protein L55provided by HGNC
Primary source
HGNC:HGNC:16686
See related
Ensembl:ENSG00000162910 MIM:611859; AllianceGenome:HGNC:16686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L55nt; MRP-L55; AAVG5835; PRO19675
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 8.8), prostate (RPKM 8.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MRPL55 in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228106685..228109299, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227295671..227298285, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228294386..228297000, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor 1 Neighboring gene microRNA 3620 Neighboring gene chromosome 1 open reading frame 35 Neighboring gene CIAO2A pseudogene 2 Neighboring gene ribosomal protein S28 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC61802, DKFZp686D1387

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in mitochondrial translation IC
Inferred by Curator
more info
PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IC
Inferred by Curator
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial large ribosomal subunit IC
Inferred by Curator
more info
PubMed 
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
39S ribosomal protein L55, mitochondrial
Names
L55mt
mitochondrial large ribosomal subunit protein bL31m
mitochondrial large ribosomal subunit protein mL55

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321284.2NP_001308213.1  39S ribosomal protein L55, mitochondrial isoform a

    Status: REVIEWED

    Source sequence(s)
    BC052806, BQ011059, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000355708.3, ENST00000366747.7
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  2. NM_181441.3NP_852106.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852106.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks a segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BM975134, BP871687, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000338189.5, ENST00000348259.9
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  3. NM_181454.3NP_852119.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses a different splice site in one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BF945771, BM706934, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000355700.1, ENST00000366739.5
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  4. NM_181455.3NP_852120.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BF945771, BM706934, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000375740.3, ENST00000391867.8
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  5. NM_181456.3NP_852121.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BI458525, BQ012917, BU597178
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000337361.5, ENST00000336300.9
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  6. NM_181462.3NP_852127.2  39S ribosomal protein L55, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_852127.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame segment when compared to variant 5. The predicted protein (isoform b) is longer than isoform a. The predicted ORF of this transcript has not been experimentally confirmed.
    Source sequence(s)
    AY358771, BI458525, BQ012917
    Consensus CDS
    CCDS44325.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    Related
    ENSP00000403614.1, ENST00000430433.5
    Conserved Domains (1) summary
    pfam09776
    Location:47161
    Mitoc_L55; Mitochondrial ribosomal protein L55
  7. NM_181463.3NP_852128.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is the most commonly occurring transcript. Variants 1, 2, 3, 5, 6, 7, 8 encode the same isoform (a).
    Source sequence(s)
    BI458525, BQ012917, BU601595
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000337342.3, ENST00000336520.8
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  8. NM_181464.3NP_852129.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852129.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses a different splice site in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BQ012917, BU594505, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000295008.4, ENST00000295008.8
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  9. NM_181465.3NP_852130.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses a different splice site in one segment and lacks an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BQ012917, BU597178, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000355707.3, ENST00000366746.7
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    228106685..228109299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446137.1XP_047302093.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  2. XM_047446143.1XP_047302099.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  3. XM_047446133.1XP_047302089.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  4. XM_005273062.4XP_005273119.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273119.1

    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000355703.1, ENST00000366742.5
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  5. XM_047446139.1XP_047302095.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  6. XM_047446096.1XP_047302052.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
    Related
    ENSP00000355695.1, ENST00000366734.5
  7. XM_047446113.1XP_047302069.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  8. XM_047446123.1XP_047302079.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
    Related
    ENSP00000355705.1, ENST00000366744.5
  9. XM_047446106.1XP_047302062.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  10. XM_005273061.6XP_005273118.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273118.1

    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  11. XM_047446095.1XP_047302051.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  12. XM_047446098.1XP_047302054.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  13. XM_005273063.6XP_005273120.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273120.1

    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  14. XM_011544095.4XP_011542397.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011542397.1

    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  15. XM_047446079.1XP_047302035.1  39S ribosomal protein L55, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6UWI8
    UniProtKB/TrEMBL
    A0A024R3U3
  16. XM_005273059.4XP_005273116.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273116.1

    UniProtKB/Swiss-Prot
    Q6UWI8, Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0, A0A024R3U3
    Related
    ENSP00000355694.1, ENST00000366733.5
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    227295671..227298285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)