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MRPL55 mitochondrial ribosomal protein L55 [ Homo sapiens (human) ]

Gene ID: 128308, updated on 1-Jun-2020

Summary

Official Symbol
MRPL55provided by HGNC
Official Full Name
mitochondrial ribosomal protein L55provided by HGNC
Primary source
HGNC:HGNC:16686
See related
Ensembl:ENSG00000162910 MIM:611859
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L55nt; MRP-L55; AAVG5835; PRO19675
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 8.8), prostate (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See MRPL55 in Genome Data Viewer
Location:
1q42.13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228106679..228111746, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228294380..228297037, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor 1 Neighboring gene microRNA 3620 Neighboring gene chromosome 1 open reading frame 35 Neighboring gene family with sequence similarity 96 member A pseudogene 2 Neighboring gene ribosomal protein S28 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC61802, DKFZp686D1387

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L55, mitochondrial
Names
L55mt
mitochondrial large ribosomal subunit protein bL31m
mitochondrial large ribosomal subunit protein mL55

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321284.1NP_001308213.1  39S ribosomal protein L55, mitochondrial isoform a

    Status: REVIEWED

    Source sequence(s)
    BC052806, BQ011059, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000355708.3, ENST00000366747.7
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  2. NM_181441.2NP_852106.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852106.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks a segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BM975134, BP871687, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000338189.5, ENST00000348259.9
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  3. NM_181454.2NP_852119.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses a different splice site in one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BF945771, BM706934, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000355700.1, ENST00000366739.5
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  4. NM_181455.2NP_852120.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BF945771, BM706934, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000375740.3, ENST00000391867.8
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  5. NM_181456.2NP_852121.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BI458525, BQ012917, BU597178, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000337361.5, ENST00000336300.9
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  6. NM_181462.2NP_852127.2  39S ribosomal protein L55, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_852127.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame segment when compared to variant 5. The predicted protein (isoform b) is longer than isoform a. The predicted ORF of this transcript has not been experimentally confirmed.
    Source sequence(s)
    AY358771, BI458525, BQ012917, CV572808
    Consensus CDS
    CCDS44325.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    Related
    ENSP00000403614.1, ENST00000430433.5
    Conserved Domains (1) summary
    pfam09776
    Location:47161
    Mitoc_L55; Mitochondrial ribosomal protein L55
  7. NM_181463.3NP_852128.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is the most commonly occurring transcript. Variants 1, 2, 3, 5, 6, 7, 8 encode the same isoform (a).
    Source sequence(s)
    BI458525, BQ012917, BU601595
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000337342.3, ENST00000336520.8
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  8. NM_181464.2NP_852129.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852129.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses a different splice site in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BQ012917, BU594505, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000295008.4, ENST00000295008.8
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  9. NM_181465.2NP_852130.1  39S ribosomal protein L55, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses a different splice site in one segment and lacks an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BQ012917, BU597178, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000355707.3, ENST00000366746.7
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    228106679..228111746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273062.3XP_005273119.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273119.1

    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000355703.1, ENST00000366742.5
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  2. XM_005273061.5XP_005273118.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273118.1

    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  3. XM_005273063.5XP_005273120.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273120.1

    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  4. XM_011544095.3XP_011542397.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011542397.1

    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  5. XM_005273059.4XP_005273116.1  39S ribosomal protein L55, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273116.1

    UniProtKB/Swiss-Prot
    Q7Z7F7
    UniProtKB/TrEMBL
    A0A024R3R0
    Related
    ENSP00000355694.1, ENST00000366733.5
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55
  6. XM_024453282.1XP_024309050.1  39S ribosomal protein L55, mitochondrial isoform X1

    Related
    ENSP00000355695.1, ENST00000366734.5
    Conserved Domains (1) summary
    pfam09776
    Location:11125
    Mitoc_L55; Mitochondrial ribosomal protein L55

RNA

  1. XR_002959482.1 RNA Sequence

  2. XR_002959481.1 RNA Sequence

  3. XR_002959480.1 RNA Sequence

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