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ARHGEF19 Rho guanine nucleotide exchange factor 19 [ Homo sapiens (human) ]

Gene ID: 128272, updated on 24-Nov-2020

Summary

Official Symbol
ARHGEF19provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 19provided by HGNC
Primary source
HGNC:HGNC:26604
See related
Ensembl:ENSG00000142632 MIM:612496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WGEF
Summary
Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]
Expression
Ubiquitous expression in skin (RPKM 10.4), thyroid (RPKM 4.9) and 22 other tissues See more
Orthologs

Genomic context

See ARHGEF19 in Genome Data Viewer
Location:
1p36.13
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (16197854..16212700, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16524599..16539104, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene EPH receptor A2 Neighboring gene uncharacterized LOC101927479 Neighboring gene Sharpr-MPRA regulatory region 8013 Neighboring gene anoctamin 7 like 1 (pseudogene) Neighboring gene ciliogenesis and planar polarity effector 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Rho guanine nucleotide exchange factor 19 (ARHGEF19) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33962

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 19
Names
Rho guanine nucleotide exchange factor (GEF) 19
ephexin-2
ephexin2
weakly similar to Rho GEF

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153213.5NP_694945.2  rho guanine nucleotide exchange factor 19

    See identical proteins and their annotated locations for NP_694945.2

    Status: VALIDATED

    Source sequence(s)
    AK297707, AL137736, BC040640
    Consensus CDS
    CCDS170.1
    UniProtKB/Swiss-Prot
    Q8IW93
    UniProtKB/TrEMBL
    B4DN02
    Related
    ENSP00000270747.3, ENST00000270747.8
    Conserved Domains (4) summary
    cd11940
    Location:719773
    SH3_ARHGEF5_19; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl28033
    Location:10353
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    16197854..16212700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540706.3XP_011539008.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_011539008.1

    UniProtKB/Swiss-Prot
    Q8IW93
    Conserved Domains (4) summary
    cd11940
    Location:719773
    SH3_ARHGEF5_19; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19
    cd01221
    Location:580706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382558
    RhoGEF; RhoGEF domain
    cl28033
    Location:10353
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RNA

  1. XR_946544.1 RNA Sequence

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