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IQGAP3 IQ motif containing GTPase activating protein 3 [ Homo sapiens (human) ]

Gene ID: 128239, updated on 23-Nov-2023

Summary

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Official Symbol
IQGAP3provided by HGNC
Official Full Name
IQ motif containing GTPase activating protein 3provided by HGNC
Primary source
HGNC:HGNC:20669
See related
Ensembl:ENSG00000183856 AllianceGenome:HGNC:20669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to act upstream of or within several processes, including intracellular signal transduction; positive regulation of macromolecule metabolic process; and positive regulation of mammary gland epithelial cell proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 5.6), duodenum (RPKM 3.0) and 16 other tissues See more
Orthologs
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Genomic context

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See IQGAP3 in Genome Data Viewer
Location:
1q22
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156525405..156572565, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155663992..155708965, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156495197..156542357, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MIR9-1 host gene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156390239-156390770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156391951-156392452 Neighboring gene microRNA 9-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:156409392-156409986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156409987-156410580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156418512-156419012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156426495-156427452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156427509-156428010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156428011-156428510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156431759-156432710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156432711-156433660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156445026-156445638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1863 Neighboring gene myocyte enhancer factor 2D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156466171-156466671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156471045-156471824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1868 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156474933-156475335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1870 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156483472-156483678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1430 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:156495835-156496406 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:156508711-156509291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554411-156554912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554913-156555412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156561722-156562568 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene NAD(P)HX epimerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability. Li W, et al. PeerJ, 2022. PMID 36275458, Free PMC Article
  2. Comprehensive Multiomics Analysis Identified IQGAP3 as a Potential Prognostic Marker in Pan-Cancer. Wang G, et al. Dis Markers, 2022. PMID 36164370, Free PMC Article
  3. Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3. Jinawath N, et al. Biomolecules, 2020 Aug 17. PMID 32824461, Free PMC Article
  4. IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation. Hu G, et al. Med Sci Monit, 2019 Oct 12. PMID 31605603, Free PMC Article
  5. High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients. Wu J, et al. Int J Biol Markers, 2019 Dec. PMID 31544570

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability.
    Title: IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability.
  2. CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway.
    Title: CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway.
  3. Comprehensive Multiomics Analysis Identified IQGAP3 as a Potential Prognostic Marker in Pan-Cancer.
    Title: Comprehensive Multiomics Analysis Identified IQGAP3 as a Potential Prognostic Marker in Pan-Cancer.
  4. lncRNA MIR4435-2HG Accelerates the Development of Bladder Cancer through Enhancing IQGAP3 and CDCA5 Expression.
    Title: lncRNA MIR4435-2HG Accelerates the Development of Bladder Cancer through Enhancing IQGAP3 and CDCA5 Expression.
  5. IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability.
    Title: IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability.
  6. Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3.
    Title: Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3.
  7. IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.
    Title: IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.
  8. IQGAP3 was upregulated in colorectal cancer at the tissue level and cellular level. Based on immunohistochemistry results of the tissue microarrays, authors demonstrated that higher expression of IQGAP3 was associated with higher tumor node metastasis stage (P = 0.005), higher incidence of lymph node metastasis (P = 0.004), and shorter overall survival (P = 0.022).
    Title: High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients.
  9. Data found that the IQGAP3/BMP4 ratio in urinary cell-free DNA (ucfDNA) was significantly associated with recurrence-free survival (RFS) and progression-free survival (PFS) in non-muscle-invasive bladder cancer (NMIBC) patients suggesting that the IQGAP3/BMP4 ratio in ucfDNA may be an important independent factor for NMIBC prognosis.
    Title: Urinary Cell-Free DNA IQGAP3/BMP4 Ratio as a Prognostic Marker for Non-Muscle-Invasive Bladder Cancer.
  10. IQGAP3 may be a potential target gene for Kaempferol in the treatment of breast cancer.
    Title: IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1947, MGC10170, MGC10831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables myosin VI light chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
  
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell size IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras GTPase-activating-like protein IQGAP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178229.5 → NP_839943.3  ras GTPase-activating-like protein IQGAP3

    Status: VALIDATED

    Source sequence(s)
    AL365181
    Consensus CDS
    CCDS1144.1
    UniProtKB/Swiss-Prot
    Q5T3H8, Q86VI3
    UniProtKB/TrEMBL
    A2RRC9
    Related
    ENSP00000354451.2, ENST00000361170.7
    Conserved Domains (3) summary
    cd12207
    Location:987 → 1336
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    cl27227
    Location:861 → 1631
    RasGAP_C; RasGAP C-terminus
    cl27381
    Location:734 → 957
    Myosin_head; Myosin head (motor domain)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156525405..156572565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445996.1 → XP_047301952.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    UniProtKB/TrEMBL
    A2RRC9

  2. XM_047445990.1 → XP_047301946.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    UniProtKB/TrEMBL
    A2RRC9

  3. XM_011509198.4 → XP_011507500.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    UniProtKB/TrEMBL
    A2RRC9
    Conserved Domains (5) summary
    smart00015
    Location:768 → 785
    IQ; Calmodulin-binding motif
    cd12207
    Location:992 → 1341
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    smart00323
    Location:981 → 1334
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:40 → 152
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam03836
    Location:1453 → 1559
    RasGAP_C; RasGAP C-terminus

  4. XM_047446003.1 → XP_047301959.1  ras GTPase-activating-like protein IQGAP3 isoform X4

    UniProtKB/TrEMBL
    F2Z2E2

  5. XM_011509201.2 → XP_011507503.1  ras GTPase-activating-like protein IQGAP3 isoform X6

    Conserved Domains (4) summary
    smart00015
    Location:267 → 284
    IQ; Calmodulin-binding motif
    cd12207
    Location:491 → 840
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    smart00323
    Location:480 → 833
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam03836
    Location:952 → 1058
    RasGAP_C; RasGAP C-terminus

  6. XM_011509200.3 → XP_011507502.1  ras GTPase-activating-like protein IQGAP3 isoform X5

    Conserved Domains (4) summary
    smart00015
    Location:321 → 338
    IQ; Calmodulin-binding motif
    cd12207
    Location:545 → 894
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    smart00323
    Location:534 → 887
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam03836
    Location:1006 → 1112
    RasGAP_C; RasGAP C-terminus

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791758.1 Reference GRCh38.p14 PATCHES

    Range
    83962..131166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332827.1 → XP_054188802.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    UniProtKB/TrEMBL
    A2RRC9

  2. XM_054332828.1 → XP_054188803.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    UniProtKB/TrEMBL
    A2RRC9

  3. XM_054332829.1 → XP_054188804.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    UniProtKB/TrEMBL
    A2RRC9

  4. XM_054332830.1 → XP_054188805.1  ras GTPase-activating-like protein IQGAP3 isoform X4

    UniProtKB/TrEMBL
    F2Z2E2

  5. XM_054332832.1 → XP_054188807.1  ras GTPase-activating-like protein IQGAP3 isoform X6

  6. XM_054332831.1 → XP_054188806.1  ras GTPase-activating-like protein IQGAP3 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155663992..155708965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334424.1 → XP_054190399.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    UniProtKB/TrEMBL
    A2RRC9

  2. XM_054334425.1 → XP_054190400.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    UniProtKB/TrEMBL
    A2RRC9

  3. XM_054334422.1 → XP_054190397.1  ras GTPase-activating-like protein IQGAP3 isoform X8

    UniProtKB/TrEMBL
    A2RRC9

  4. XM_054334421.1 → XP_054190396.1  ras GTPase-activating-like protein IQGAP3 isoform X7

    UniProtKB/TrEMBL
    A2RRC9

  5. XM_054334426.1 → XP_054190401.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    UniProtKB/TrEMBL
    A2RRC9

  6. XM_054334423.1 → XP_054190398.1  ras GTPase-activating-like protein IQGAP3 isoform X9

    UniProtKB/TrEMBL
    A2RRC9

  7. XM_054334427.1 → XP_054190402.1  ras GTPase-activating-like protein IQGAP3 isoform X10

    UniProtKB/TrEMBL
    F2Z2E2

  8. XM_054334429.1 → XP_054190404.1  ras GTPase-activating-like protein IQGAP3 isoform X6

  9. XM_054334428.1 → XP_054190403.1  ras GTPase-activating-like protein IQGAP3 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86VI3.2 GenPept UniProtKB/Swiss-Prot:Q86VI3

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