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IQGAP3 IQ motif containing GTPase activating protein 3 [ Homo sapiens (human) ]

Gene ID: 128239, updated on 2-Mar-2021

Summary

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Official Symbol
IQGAP3provided by HGNC
Official Full Name
IQ motif containing GTPase activating protein 3provided by HGNC
Primary source
HGNC:HGNC:20669
See related
Ensembl:ENSG00000183856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in bone marrow (RPKM 5.6), duodenum (RPKM 3.0) and 16 other tissues See more
Orthologs
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Genomic context

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See IQGAP3 in Genome Data Viewer
Location:
1q22
Exon count:
41
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156525405..156572605, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156495197..156542357, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MIR9-1 host gene Neighboring gene microRNA 9-1 Neighboring gene myocyte enhancer factor 2D Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene G-patch domain containing 4 Neighboring gene NAD(P)HX epimerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation. Hu G, et al. Med Sci Monit, 2019 Oct 12. PMID 31605603, Free PMC Article
  2. High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients. Wu J, et al. Int J Biol Markers, 2019 Dec. PMID 31544570
  3. Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer. Oue N, et al. Pathobiology, 2018. PMID 29131081
  4. Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma. Shi Y, et al. J Transl Med, 2017 Aug 15. PMID 28810875, Free PMC Article
  5. RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells. Hu G, et al. Oncol Res, 2016 Oct 27. PMID 28281966, Free PMC Article

See all (55) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IQGAP3 was upregulated in colorectal cancer at the tissue level and cellular level. Based on immunohistochemistry results of the tissue microarrays, authors demonstrated that higher expression of IQGAP3 was associated with higher tumor node metastasis stage (P = 0.005), higher incidence of lymph node metastasis (P = 0.004), and shorter overall survival (P = 0.022).
    Title: High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients.
  2. Data found that the IQGAP3/BMP4 ratio in urinary cell-free DNA (ucfDNA) was significantly associated with recurrence-free survival (RFS) and progression-free survival (PFS) in non-muscle-invasive bladder cancer (NMIBC) patients suggesting that the IQGAP3/BMP4 ratio in ucfDNA may be an important independent factor for NMIBC prognosis.
    Title: Urinary Cell-Free DNA IQGAP3/BMP4 Ratio as a Prognostic Marker for Non-Muscle-Invasive Bladder Cancer.
  3. IQGAP3 may be a potential target gene for Kaempferol in the treatment of breast cancer.
    Title: IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.
  4. Both IQGAP3/BMP4 and IQGAP3/FAM107A ratios in ucfDNA were significantly higher in patients with BC than in those with hematuria.
    Title: Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria.
  5. These results suggest that IQGAP3 plays an important role in gastric cancer stem cells (CSCs). The location of IQGAP3 on the cell membrane makes it a potential therapeutic target for gastric cancer (GC).
    Title: Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer.
  6. IQGAP3 functions as an important regulator of metastasis and epithelial-to-mesenchymal transition by constitutively activating the TGF-beta signaling pathway in Hepatocellular carcinoma.
    Title: Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma.
  7. IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability
    Title: Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.
  8. IQGAP3 may be a potential therapeutic target in human breast cancer.
    Title: RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.
  9. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review)
    Title: The biology of IQGAP proteins: beyond the cytoskeleton.
  10. Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis.
    Title: Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1947, MGC10170, MGC10831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
myosin VI light chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
  
cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
  
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
positive regulation of mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of cell size IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytosol TAS
Traceable Author Statement
more info
  
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras GTPase-activating-like protein IQGAP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178229.5 → NP_839943.3  ras GTPase-activating-like protein IQGAP3

    Status: VALIDATED

    Source sequence(s)
    AL365181
    Consensus CDS
    CCDS1144.1
    Related
    ENSP00000354451.2, ENST00000361170.7
    Conserved Domains (3) summary
    cd12207
    Location:987 → 1336
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    cl27227
    Location:861 → 1631
    RasGAP_C; RasGAP C-terminus
    cl27381
    Location:734 → 957
    Myosin_head; Myosin head (motor domain)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156525405..156572605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453275.1 → XP_024309043.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    Conserved Domains (3) summary
    cd12207
    Location:994 → 1343
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    cl27227
    Location:868 → 1638
    RasGAP_C; RasGAP C-terminus
    cl27381
    Location:741 → 964
    Myosin_head; Myosin head (motor domain)

  2. XM_024453274.1 → XP_024309042.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    Conserved Domains (3) summary
    cd12207
    Location:998 → 1347
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    cl27227
    Location:872 → 1642
    RasGAP_C; RasGAP C-terminus
    cl27381
    Location:745 → 968
    Myosin_head; Myosin head (motor domain)

  3. XM_011509198.3 → XP_011507500.1  ras GTPase-activating-like protein IQGAP3 isoform X4

    Conserved Domains (5) summary
    smart00015
    Location:768 → 785
    IQ; Calmodulin-binding motif
    cd12207
    Location:992 → 1341
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    smart00323
    Location:981 → 1334
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:40 → 152
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam03836
    Location:1453 → 1559
    RasGAP_C; RasGAP C-terminus

  4. XM_024453273.1 → XP_024309041.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    Conserved Domains (3) summary
    cd12207
    Location:999 → 1348
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    cl27227
    Location:873 → 1643
    RasGAP_C; RasGAP C-terminus
    cl27381
    Location:746 → 969
    Myosin_head; Myosin head (motor domain)

  5. XM_024453276.1 → XP_024309044.1  ras GTPase-activating-like protein IQGAP3 isoform X5

    Conserved Domains (3) summary
    cd12207
    Location:860 → 1209
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    cl27227
    Location:734 → 1504
    RasGAP_C; RasGAP C-terminus
    cl27381
    Location:607 → 830
    Myosin_head; Myosin head (motor domain)

  6. XM_011509201.2 → XP_011507503.1  ras GTPase-activating-like protein IQGAP3 isoform X7

    Conserved Domains (4) summary
    smart00015
    Location:267 → 284
    IQ; Calmodulin-binding motif
    cd12207
    Location:491 → 840
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    smart00323
    Location:480 → 833
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam03836
    Location:952 → 1058
    RasGAP_C; RasGAP C-terminus

  7. XM_011509200.2 → XP_011507502.1  ras GTPase-activating-like protein IQGAP3 isoform X6

    Conserved Domains (4) summary
    smart00015
    Location:321 → 338
    IQ; Calmodulin-binding motif
    cd12207
    Location:545 → 894
    RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
    smart00323
    Location:534 → 887
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam03836
    Location:1006 → 1112
    RasGAP_C; RasGAP C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86VI3.2 GenPept UniProtKB/Swiss-Prot:Q86VI3

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