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TSACC TSSK6 activating cochaperone [ Homo sapiens (human) ]

Gene ID: 128229, updated on 21-Dec-2019

Summary

Official Symbol
TSACCprovided by HGNC
Official Full Name
TSSK6 activating cochaperoneprovided by HGNC
Primary source
HGNC:HGNC:30636
See related
Ensembl:ENSG00000163467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; SSTK-IP; C1orf182
Expression
Restricted expression toward testis (RPKM 148.3) See more
Orthologs

Genomic context

See TSACC in Genome Data Viewer
Location:
1q22
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156337314..156346995)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156307105..156316786)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glycosylated lysosomal membrane protein Neighboring gene VHL like Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene Rh family B glycoprotein (gene/pseudogene) Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC26877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TSSK6-activating co-chaperone protein
Names
SSTK-interacting protein (SSTK-IP)
TSSK6 activating co-chaperone

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304817.2NP_001291746.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AK311950, BC014605, DB446801
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    Q96A04
    Related
    ENSP00000357237.1, ENST00000368254.5
    Conserved Domains (1) summary
    pfam15836
    Location:1125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  2. NM_001304818.2NP_001291747.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AY048672, DB446801
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    Q96A04
    Related
    ENSP00000357236.1, ENST00000368253.6
    Conserved Domains (1) summary
    pfam15836
    Location:1125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  3. NM_001304819.2NP_001291748.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AL589685, BC014605, HY019225, HY044099
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    Q96A04
    Related
    ENSP00000357235.1, ENST00000368252.5
    Conserved Domains (1) summary
    pfam15836
    Location:1125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  4. NM_001304820.1NP_001291749.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AI336861, BC014605
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    Q96A04
    Related
    ENSP00000357234.1, ENST00000368251.1
    Conserved Domains (1) summary
    pfam15836
    Location:1125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  5. NM_001304821.2NP_001291750.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AL589685, BC014605, HY044099, HY230397
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    Q96A04
    Conserved Domains (1) summary
    pfam15836
    Location:1125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  6. NM_001304822.2NP_001291751.1  TSSK6-activating co-chaperone protein isoform b

    See identical proteins and their annotated locations for NP_001291751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    BC014605, HY044771
    Consensus CDS
    CCDS76223.1
    UniProtKB/Swiss-Prot
    Q96A04
    UniProtKB/TrEMBL
    V9GYT6
    Conserved Domains (1) summary
    pfam15836
    Location:157
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  7. NM_001304823.2NP_001291752.1  TSSK6-activating co-chaperone protein isoform b

    See identical proteins and their annotated locations for NP_001291752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    BC014605, HY034095
    Consensus CDS
    CCDS76223.1
    UniProtKB/Swiss-Prot
    Q96A04
    UniProtKB/TrEMBL
    V9GYT6
    Related
    ENSP00000477074.1, ENST00000470342.5
    Conserved Domains (1) summary
    pfam15836
    Location:157
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  8. NM_001304824.2NP_001291753.1  TSSK6-activating co-chaperone protein isoform b

    See identical proteins and their annotated locations for NP_001291753.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    AL589685, BC014605, BE464129, HY044099
    Consensus CDS
    CCDS76223.1
    UniProtKB/Swiss-Prot
    Q96A04
    UniProtKB/TrEMBL
    V9GYT6
    Related
    ENSP00000477010.1, ENST00000466306.5
    Conserved Domains (1) summary
    pfam15836
    Location:157
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  9. NM_001304825.2NP_001291754.1  TSSK6-activating co-chaperone protein isoform b

    See identical proteins and their annotated locations for NP_001291754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    AL589685, BC014605, BI831108, HY044099
    Consensus CDS
    CCDS76223.1
    UniProtKB/Swiss-Prot
    Q96A04
    UniProtKB/TrEMBL
    V9GYT6
    Related
    ENSP00000476780.1, ENST00000481479.5
    Conserved Domains (1) summary
    pfam15836
    Location:157
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  10. NM_001304826.2NP_001291755.1  TSSK6-activating co-chaperone protein isoform c

    See identical proteins and their annotated locations for NP_001291755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and uses two alternate splice junctions at the 5' end compared to variant 1. The resulting isoform (c) is longer at the N-terminus compared to isoform a.
    Source sequence(s)
    AL589685, AY048673, HY044099
    UniProtKB/Swiss-Prot
    Q96A04
    Conserved Domains (1) summary
    pfam15836
    Location:19143
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
  11. NM_144627.4NP_653228.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_653228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AL589685, BC014605
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    Q96A04
    Related
    ENSP00000357238.3, ENST00000368255.7
    Conserved Domains (1) summary
    pfam15836
    Location:1125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

RNA

  1. NR_130913.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs at the 5' end, lacks an alternate internal exon, and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC014605, DB446801, HY048925

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156337314..156346995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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