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TMEM125 transmembrane protein 125 [ Homo sapiens (human) ]

Gene ID: 128218, updated on 22-Sep-2022

Summary

Official Symbol
TMEM125provided by HGNC
Official Full Name
transmembrane protein 125provided by HGNC
Primary source
HGNC:HGNC:28275
See related
Ensembl:ENSG00000179178 AllianceGenome:HGNC:28275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung (RPKM 30.3), thyroid (RPKM 11.2) and 12 other tissues See more
Orthologs
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Genomic context

See TMEM125 in Genome Data Viewer
Location:
1p34.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43269983..43274002)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43140490..43144509)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43735654..43739673)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378685 Neighboring gene cilia and flagella associated protein 57 Neighboring gene RNA, 5S ribosomal pseudogene 46 Neighboring gene uncharacterized LOC124904164 Neighboring gene chromosome 1 open reading frame 210 Neighboring gene tyrosine kinase with immunoglobulin like and EGF like domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Clone Names

  • MGC17299

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320244.2NP_001307173.1  transmembrane protein 125

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093420, BC072393, BI768096
    Consensus CDS
    CCDS480.1
    UniProtKB/Swiss-Prot
    D3DPX1, Q96AQ2
    Related
    ENSP00000429275.1, ENST00000432792.6
    Conserved Domains (1) summary
    pfam15109
    Location:20114
    TMEM125; TMEM125 protein family
  2. NM_144626.3NP_653227.1  transmembrane protein 125

    See identical proteins and their annotated locations for NP_653227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093420, BI768096, BI821566, BM677938
    Consensus CDS
    CCDS480.1
    UniProtKB/Swiss-Prot
    D3DPX1, Q96AQ2
    Related
    ENSP00000429775.1, ENST00000439858.6
    Conserved Domains (1) summary
    pfam15109
    Location:20114
    TMEM125; TMEM125 protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    43269983..43274002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540705.3XP_011539007.1  transmembrane protein 125 isoform X1

    See identical proteins and their annotated locations for XP_011539007.1

    UniProtKB/Swiss-Prot
    D3DPX1, Q96AQ2
    Conserved Domains (1) summary
    pfam15109
    Location:20114
    TMEM125; TMEM125 protein family
  2. XM_047445955.1XP_047301911.1  transmembrane protein 125 isoform X1

    UniProtKB/Swiss-Prot
    D3DPX1
  3. XM_005270467.5XP_005270524.1  transmembrane protein 125 isoform X1

    See identical proteins and their annotated locations for XP_005270524.1

    UniProtKB/Swiss-Prot
    D3DPX1, Q96AQ2
    Conserved Domains (1) summary
    pfam15109
    Location:20114
    TMEM125; TMEM125 protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    43140490..43144509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)