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TMEM125 transmembrane protein 125 [ Homo sapiens (human) ]

Gene ID: 128218, updated on 1-Aug-2020

Summary

Official Symbol
TMEM125provided by HGNC
Official Full Name
transmembrane protein 125provided by HGNC
Primary source
HGNC:HGNC:28275
See related
Ensembl:ENSG00000179178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in lung (RPKM 30.3), thyroid (RPKM 11.2) and 12 other tissues See more
Orthologs

Genomic context

See TMEM125 in Genome Data Viewer
Location:
1p34.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (43269865..43274002)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43735665..43739673)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378685 Neighboring gene EBNA1 binding protein 2 Neighboring gene microRNA 6733 Neighboring gene cilia and flagella associated protein 57 Neighboring gene RNA, 5S ribosomal pseudogene 46 Neighboring gene chromosome 1 open reading frame 210 Neighboring gene tyrosine kinase with immunoglobulin like and EGF like domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Clone Names

  • MGC17299

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320244.2NP_001307173.1  transmembrane protein 125

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093420, BC072393, BI768096
    Consensus CDS
    CCDS480.1
    UniProtKB/Swiss-Prot
    Q96AQ2
    Related
    ENSP00000429275.1, ENST00000432792.6
    Conserved Domains (1) summary
    pfam15109
    Location:18114
    TMEM125; TMEM125 protein family
  2. NM_144626.3NP_653227.1  transmembrane protein 125

    See identical proteins and their annotated locations for NP_653227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093420, BI768096, BI821566, BM677938
    Consensus CDS
    CCDS480.1
    UniProtKB/Swiss-Prot
    Q96AQ2
    Related
    ENSP00000429775.1, ENST00000439858.6
    Conserved Domains (1) summary
    pfam15109
    Location:18114
    TMEM125; TMEM125 protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    43269865..43274002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270467.4XP_005270524.1  transmembrane protein 125 isoform X1

    See identical proteins and their annotated locations for XP_005270524.1

    UniProtKB/Swiss-Prot
    Q96AQ2
    Conserved Domains (1) summary
    pfam15109
    Location:18114
    TMEM125; TMEM125 protein family
  2. XM_011540705.2XP_011539007.1  transmembrane protein 125 isoform X1

    See identical proteins and their annotated locations for XP_011539007.1

    UniProtKB/Swiss-Prot
    Q96AQ2
    Conserved Domains (1) summary
    pfam15109
    Location:18114
    TMEM125; TMEM125 protein family
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