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KLF17 Kruppel like factor 17 [ Homo sapiens (human) ]

Gene ID: 128209, updated on 28-Jun-2020

Summary

Official Symbol
KLF17provided by HGNC
Official Full Name
Kruppel like factor 17provided by HGNC
Primary source
HGNC:HGNC:18830
See related
Ensembl:ENSG00000171872 MIM:609602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZLF393; ZNF393; Zfp393
Expression
Biased expression in testis (RPKM 3.2), endometrium (RPKM 0.4) and 5 other tissues See more
Orthologs

Genomic context

See KLF17 in Genome Data Viewer
Location:
1p34.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (44043927..44135140)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44513987..44600812)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 24 Neighboring gene solute carrier family 6 member 9 Neighboring gene uncharacterized LOC107984948 Neighboring gene VISTA enhancer hs1857 Neighboring gene keratin 8 pseudogene 47 Neighboring gene small nuclear ribonucleoprotein Sm D1 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 479, pseudogene Neighboring gene zinc finger protein 146 pseudogene Neighboring gene Kruppel like factor 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40160

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 17
Names
novel zinc-finger protein
zinc finger protein 393

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173484.4NP_775755.3  Krueppel-like factor 17

    See identical proteins and their annotated locations for NP_775755.3

    Status: VALIDATED

    Source sequence(s)
    AL356653, BC049844, DB046781
    Consensus CDS
    CCDS508.1
    UniProtKB/Swiss-Prot
    Q5JT82
    Related
    ENSP00000361373.3, ENST00000372299.4
    Conserved Domains (4) summary
    COG5048
    Location:282350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:343365
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:329352
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    44043927..44135140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540700.1XP_011539002.1  Krueppel-like factor 17 isoform X1

    See identical proteins and their annotated locations for XP_011539002.1

    Conserved Domains (4) summary
    COG5048
    Location:245313
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:306328
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:292315
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005270465.3XP_005270522.2  Krueppel-like factor 17 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:108211
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175197
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:233255
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:219242
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011540704.2XP_011539006.1  Krueppel-like factor 17 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:145232
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:156178
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:214236
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200223
    zf-H2C2_2; Zinc-finger double domain
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