Cobl cordon-bleu WH2 repeat [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coblprovided by MGI
Official Full Name: cordon-bleu WH2 repeatprovided by MGI
Primary source: MGI:MGI:105056
See related: Ensembl:ENSMUSG00000020173 AllianceGenome:MGI:105056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables actin monomer binding activity. Involved in actin filament organization; collateral sprouting in absence of injury; and positive regulation of cell projection organization. Acts upstream of or within several processes, including chordate embryonic development; liver development; and notochord development. Located in several cellular components, including growth cone; ruffle; and terminal web. Colocalizes with actin filament. Is expressed in several structures, including central nervous system; chordamesoderm; embryo mesenchyme; gut; and nose. Orthologous to human COBL (cordon-bleu WH2 repeat protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 10.7), cortex adult (RPKM 8.5) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 7.3 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (12186676..12415022, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (12236676..12465022, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Poststroke dendritic arbor regrowth requires the actin nucleator Cobl.
Title: Poststroke dendritic arbor regrowth requires the actin nucleator Cobl.
Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
Title: Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
The actin nucleator Cobl organises the terminal web of enterocytes.
Title: The actin nucleator Cobl organises the terminal web of enterocytes.
these results provide insight as to how COBL contributes to the assembly of actin-based structures such as epithelial microvilli.
Title: Impact of cordon-bleu expression on actin cytoskeleton architecture and dynamics.
Cobl is localized to the basal region of microvilli both to participate in length regulation and to recruit BAR proteins.
Title: Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domains.
F-actin-anchored Cobl/Abp1 complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells in the cerebellar cortex.
Title: The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.
Cobl/syndapin complexes form in vivo, as demonstrated by colocalization, coimmunoprecipitation and subcellular recruitment studies.
Title: The functions of the actin nucleator Cobl in cellular morphogenesis critically depend on syndapin I.
cobl interacts with the neurulation gene Vangl2 to facilitate midbrain neural tube closure, demonstrating roles for both cobl and Vangl2 in midbrain neurulation.
Title: Cordon-bleu is a conserved gene involved in neural tube formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548182

NoName (e-PCR)
- UniSTS:548183

D11Mit2 (e-PCR), detects polymorphism
- UniSTS:126398

Homology

Homologs of the Cobl gene: The Cobl gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 303 organisms have orthologs with human gene Cobl
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables actin monomer binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin crosslink formation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in actin filament network formation	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collateral sprouting in absence of injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic axis specification	IEP Inferred from Expression Pattern more info	PubMed
involved_in floor plate development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in notochord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ruffle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in somite specification	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info	PubMed
colocalizes_with actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in axonal growth cone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic growth cone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in dendritic growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
is_active_in terminal web	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in terminal web	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein cordon-bleu

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282993.2 → NP_001269922.1 protein cordon-bleu isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL669822, AL713914

Consensus CDS

CCDS70144.1

UniProtKB/TrEMBL

G5E8P4

Related

ENSMUSP00000105278.3, ENSMUST00000109651.9

Conserved Domains (1) summary

pfam09469
Location:152 → 229

Cobl; Cordon-bleu ubiquitin-like domain
NM_001282994.2 → NP_001269923.1 protein cordon-bleu isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AL669822, AL713914

Consensus CDS

CCDS70142.1

UniProtKB/TrEMBL

G3UWY3

Related

ENSMUSP00000133470.2, ENSMUST00000174874.8

Conserved Domains (1) summary

pfam09469
Location:145 → 222

Cobl; Cordon-bleu ubiquitin-like domain
NM_001401095.1 → NP_001388024.1 protein cordon-bleu isoform 4

Status: VALIDATED

Source sequence(s)

AL669822, AL713914
NM_001401096.1 → NP_001388025.1 protein cordon-bleu isoform 5

Status: VALIDATED

Source sequence(s)

AL669822, AL713914
NM_001401097.1 → NP_001388026.1 protein cordon-bleu isoform 6

Status: VALIDATED

Source sequence(s)

AL669822, AL713914
NM_001401098.1 → NP_001388027.1 protein cordon-bleu isoform 7

Status: VALIDATED

Source sequence(s)

AL669822, AL713914
NM_001401099.1 → NP_001388028.1 protein cordon-bleu isoform 8

Status: VALIDATED

Source sequence(s)

AL669822, AL713914
NM_001401100.1 → NP_001388029.1 protein cordon-bleu isoform 9

Status: VALIDATED

Source sequence(s)

AL669822, AL713914
NM_172496.4 → NP_766084.3 protein cordon-bleu isoform 1

See identical proteins and their annotated locations for NP_766084.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL669822, AL713914

Consensus CDS

CCDS36113.1

UniProtKB/Swiss-Prot

Q5NBX1, Q8CIM4

Related

ENSMUSP00000045693.8, ENSMUST00000046755.14

Conserved Domains (1) summary

pfam09469
Location:152 → 229

Cobl; Cordon-bleu ubiquitin-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

12186676..12415022 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514485.4 → XP_006514548.1 protein cordon-bleu isoform X10

UniProtKB/Swiss-Prot

Q5NBX1

Related

ENSMUSP00000105277.2, ENSMUST00000109650.8

Conserved Domains (1) summary

pfam09469
Location:152 → 229

Cobl; Cordon-bleu ubiquitin-like domain
XM_030245514.1 → XP_030101374.1 protein cordon-bleu isoform X9

Conserved Domains (1) summary

pfam09469
Location:152 → 229

Cobl; Cordon-bleu ubiquitin-like domain
XM_011243655.4 → XP_011241957.1 protein cordon-bleu isoform X6

Conserved Domains (1) summary

pfam09469
Location:152 → 229

Cobl; Cordon-bleu ubiquitin-like domain
XM_036156272.1 → XP_036012165.1 protein cordon-bleu isoform X8

Conserved Domains (4) summary

pfam09469
Location:152 → 229

Cobl; Cordon-bleu ubiquitin-like domain

cd21799
Location:1118 → 1150

WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins

cd21800
Location:1164 → 1207

WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins

cd21801
Location:1252 → 1277

WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins
XM_011243653.4 → XP_011241955.1 protein cordon-bleu isoform X4

Conserved Domains (1) summary

pfam09469
Location:152 → 229

Cobl; Cordon-bleu ubiquitin-like domain
XM_011243654.3 → XP_011241956.1 protein cordon-bleu isoform X5

Conserved Domains (1) summary

pfam09469
Location:152 → 228

Cobl; Cordon-bleu ubiquitin-like domain
XM_011243656.3 → XP_011241958.1 protein cordon-bleu isoform X7

Conserved Domains (1) summary

pfam09469
Location:152 → 228

Cobl; Cordon-bleu ubiquitin-like domain
XM_006514481.4 → XP_006514544.1 protein cordon-bleu isoform X2

Conserved Domains (1) summary

pfam09469
Location:152 → 228

Cobl; Cordon-bleu ubiquitin-like domain
XM_011243651.4 → XP_011241953.1 protein cordon-bleu isoform X1

Conserved Domains (1) summary

pfam09469
Location:152 → 228

Cobl; Cordon-bleu ubiquitin-like domain
XM_011243652.4 → XP_011241954.1 protein cordon-bleu isoform X3

Conserved Domains (1) summary

pfam09469
Location:141 → 217

Cobl; Cordon-bleu ubiquitin-like domain
XM_036156273.1 → XP_036012166.1 protein cordon-bleu isoform X11

Related

ENSMUSP00000134372.2, ENSMUST00000172956.8

Conserved Domains (1) summary

pfam09469
Location:152 → 229

Cobl; Cordon-bleu ubiquitin-like domain
XM_030245515.2 → XP_030101375.1 protein cordon-bleu isoform X12

Conserved Domains (1) summary

pfam09469
Location:136 → 213

Cobl; Cordon-bleu ubiquitin-like domain