U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cntfr ciliary neurotrophic factor receptor [ Mus musculus (house mouse) ]

Gene ID: 12804, updated on 18-Apr-2024

Summary

Official Symbol
Cntfrprovided by MGI
Official Full Name
ciliary neurotrophic factor receptorprovided by MGI
Primary source
MGI:MGI:99605
See related
Ensembl:ENSMUSG00000028444 AllianceGenome:MGI:99605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cntfralpha
Summary
This gene encodes the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor that triggers the assembly of a trimolecular complex upon binding to CNTF, and initiate a downstream signaling process. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-linked cell surface protein. Mice lacking the encoded protein die shortly after birth and exhibit a reduction of motoneuron number at birth. The transgenic disruption of this gene specifically in the skeletal muscle followed by a peripheral nerve lesion impairs motor neuron axonal regeneration across the lesion site. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Expression
Broad expression in adrenal adult (RPKM 8.1), cerebellum adult (RPKM 6.8) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
4 A5; 4 21.81 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41657498..41697091, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41657498..41697091, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal intermediate chain 1 Neighboring gene predicted gene 12405 Neighboring gene energy homeostasis associated Neighboring gene STARR-seq mESC enhancer starr_10037 Neighboring gene STARR-positive B cell enhancer ABC_E11235 Neighboring gene ribonuclease P/MRP 25 subunit-like Neighboring gene dynactin 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ciliary neurotrophic factor receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
contributes_to ciliary neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ciliary neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CNTFR-CLCF1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CNTFR-CLCF1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ciliary neurotrophic factor receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ciliary neurotrophic factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ciliary neurotrophic factor receptor subunit alpha
Names
CNTF receptor subunit alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136056.4NP_001129528.1  ciliary neurotrophic factor receptor subunit alpha preproprotein

    See identical proteins and their annotated locations for NP_001129528.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL831723
    Consensus CDS
    CCDS18067.1
    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Related
    ENSMUSP00000100026.4, ENSMUST00000102961.10
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]
  2. NM_001379211.1NP_001366140.1  ciliary neurotrophic factor receptor subunit alpha preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL831723
    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]
  3. NM_001379212.1NP_001366141.1  ciliary neurotrophic factor receptor subunit alpha preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL831723
    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]
  4. NM_001379213.1NP_001366142.1  ciliary neurotrophic factor receptor subunit alpha preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL831723
    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]
  5. NM_001379214.1NP_001366143.1  ciliary neurotrophic factor receptor subunit alpha preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL831723
    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]
  6. NM_001379215.1NP_001366144.1  ciliary neurotrophic factor receptor subunit alpha preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL831723
    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]
  7. NM_001379216.1NP_001366145.1  ciliary neurotrophic factor receptor subunit alpha preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL831723
    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]
  8. NM_001403746.1NP_001390675.1  ciliary neurotrophic factor receptor subunit alpha precursor

    Status: REVIEWED

    Source sequence(s)
    AL831723
    UniProtKB/Swiss-Prot
    O88507, Q80T01
  9. NM_001403747.1NP_001390676.1  ciliary neurotrophic factor receptor subunit alpha precursor

    Status: REVIEWED

    Source sequence(s)
    AL831723
    UniProtKB/Swiss-Prot
    O88507, Q80T01
  10. NM_016673.3NP_057882.2  ciliary neurotrophic factor receptor subunit alpha preproprotein

    See identical proteins and their annotated locations for NP_057882.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL831723
    Consensus CDS
    CCDS18067.1
    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Related
    ENSMUSP00000100027.4, ENSMUST00000102962.10
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41657498..41697091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253151.1XP_030109011.1  ciliary neurotrophic factor receptor subunit alpha isoform X2

    UniProtKB/Swiss-Prot
    O88507, Q80T01
    UniProtKB/TrEMBL
    C9K0Z6, Q3UVR2
    Conserved Domains (3) summary
    smart00408
    Location:3996
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:204300
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:3947
    Ig; Ig strand B [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001146080.1: Suppressed sequence

    Description
    NM_001146080.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.