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Cnr2 cannabinoid receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12802, updated on 12-May-2024

Summary

Official Symbol
Cnr2provided by MGI
Official Full Name
cannabinoid receptor 2provided by MGI
Primary source
MGI:MGI:104650
See related
Ensembl:ENSMUSG00000062585 AllianceGenome:MGI:104650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CB2; CB-2; CB2-R
Summary
Predicted to enable cannabinoid receptor activity. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in dendrite; endoplasmic reticulum; and neuronal cell body. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CNR2 (cannabinoid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 19.7), mammary gland adult (RPKM 6.0) and 6 other tissues See more
Orthologs
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Genomic context

See Cnr2 in Genome Data Viewer
Location:
4 D3; 4 68.01 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135622500..135647530)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135895189..135920219)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135411492-135411675 Neighboring gene STARR-positive B cell enhancer ABC_E7999 Neighboring gene serine and arginine-rich splicing factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E4683 Neighboring gene STARR-positive B cell enhancer ABC_E1660 Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene STARR-seq mESC enhancer starr_11738 Neighboring gene STARR-positive B cell enhancer ABC_E8000 Neighboring gene STARR-positive B cell enhancer ABC_E4684 Neighboring gene STARR-seq mESC enhancer starr_11739 Neighboring gene STARR-positive B cell enhancer ABC_E4685 Neighboring gene fucosidase, alpha-L- 1, tissue Neighboring gene STARR-positive B cell enhancer ABC_E4686 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cannabinoid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cannabinoid receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cannabinoid receptor 2
Names
cannabinoid receptor 2 (macrophage)
cannabinoid receptor 2 (spleen)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305278.2NP_001292207.1  cannabinoid receptor 2

    See identical proteins and their annotated locations for NP_001292207.1

    Status: VALIDATED

    Source sequence(s)
    AL672076
    Consensus CDS
    CCDS18793.1
    UniProtKB/Swiss-Prot
    P47936, Q544H5
    Related
    ENSMUSP00000069957.4, ENSMUST00000068830.4
    Conserved Domains (2) summary
    pfam00001
    Location:50299
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:42314
    7tm_4; Olfactory receptor
  2. NM_009924.5NP_034054.3  cannabinoid receptor 2

    See identical proteins and their annotated locations for NP_034054.3

    Status: VALIDATED

    Source sequence(s)
    AL672076
    Consensus CDS
    CCDS18793.1
    UniProtKB/Swiss-Prot
    P47936, Q544H5
    Related
    ENSMUSP00000095454.3, ENSMUST00000097843.9
    Conserved Domains (2) summary
    pfam00001
    Location:50299
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:42314
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135622500..135647530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)