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Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase [ Mus musculus (house mouse) ]

Gene ID: 12799, updated on 9-Jul-2024

Summary

Official Symbol
Cnpprovided by MGI
Official Full Name
2',3'-cyclic nucleotide 3' phosphodiesteraseprovided by MGI
Primary source
MGI:MGI:88437
See related
Ensembl:ENSMUSG00000006782 AllianceGenome:MGI:88437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cnp1; Cnp-1; CNPase
Summary
Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Acts upstream of or within adult locomotory behavior; neurogenesis; and response to toxic substance. Located in cytoplasm; membrane; and myelin sheath. Is expressed in adrenal gland; central nervous system; gut; peripheral nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 129.1), cortex adult (RPKM 94.5) and 13 other tissues See more
Orthologs
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Genomic context

See Cnp in Genome Data Viewer
Location:
11 D; 11 63.47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100465765..100472565)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100574909..100591875)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA serine 1 (anticodon GGA) Neighboring gene STARR-positive B cell enhancer ABC_E5277 Neighboring gene outer dynein arm complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E8995 Neighboring gene STARR-positive B cell enhancer ABC_E7060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100443371-100443554 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene STARR-positive B cell enhancer ABC_E4000 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene STARR-positive B cell enhancer ABC_E2369 Neighboring gene STARR-positive B cell enhancer ABC_E7062 Neighboring gene NFKB inhibitor interacting Ras-like protein 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclic nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath adaxonal region ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in pseudopodium ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Names
cyclic nucleotide phosphodiesterase 1
NP_001139790.1
NP_034053.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146318.1NP_001139790.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 1

    See identical proteins and their annotated locations for NP_001139790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1). This isoform is also known as CNP1.
    Source sequence(s)
    AK087415, BY596086, M31810
    UniProtKB/TrEMBL
    Q3TYL9
    Related
    ENSMUST00000150414.8
    Conserved Domains (2) summary
    pfam05881
    Location:166399
    CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
    pfam13671
    Location:32145
    AAA_33; AAA domain
  2. NM_009923.2NP_034053.2  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 2

    See identical proteins and their annotated locations for NP_034053.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at an upstream start codon, compared to variant 1. The encoded protein (isoform 2) is 20 aa longer at the N-terminus, compared to isoform 1. This isoform is also known as CNP2.
    Source sequence(s)
    AK087415, AK158318, BY333311, BY596086
    Consensus CDS
    CCDS25427.1
    UniProtKB/Swiss-Prot
    P16330, Q61424, Q8C7C9, Q91V42, Q923F3
    UniProtKB/TrEMBL
    Q3TYV5
    Related
    ENSMUSP00000099409.5, ENSMUST00000103120.5
    Conserved Domains (2) summary
    pfam05881
    Location:186398
    CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
    cl17190
    Location:51165
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100465765..100472565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)