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UHMK1 U2AF homology motif kinase 1 [ Homo sapiens (human) ]

Gene ID: 127933, updated on 16-Feb-2020

Summary

Official Symbol
UHMK1provided by HGNC
Official Full Name
U2AF homology motif kinase 1provided by HGNC
Primary source
HGNC:HGNC:19683
See related
Ensembl:ENSG00000152332 MIM:608849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIS; KIST; P-CIP2
Summary
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in kidney (RPKM 18.6), lymph node (RPKM 18.0) and 25 other tissues See more
Orthologs

Genomic context

See UHMK1 in Genome Data Viewer
Location:
1q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (162497174..162529631)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (162466964..162499419)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 1B Neighboring gene SLAM family member 6 pseudogene 1 Neighboring gene uncharacterized LOC105371497 Neighboring gene uncharacterized LOC102724358 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 2 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23015, DKFZp434C1613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IC
Inferred by Curator
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transferase activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
midbody IDA
Inferred from Direct Assay
more info
 
neuronal ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal ribonucleoprotein granule ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase Kist
Names
KIS protein kinase
PAM COOH-terminal interactor protein 2
U2AF homology motif (UHM) kinase 1
kinase interacting with leukemia-associated gene (stathmin)
NP_001171692.1
NP_653225.2
NP_787062.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050728.1 RefSeqGene

    Range
    5645..37458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184763.1NP_001171692.1  serine/threonine-protein kinase Kist isoform 2

    See identical proteins and their annotated locations for NP_001171692.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK058195, AL359699
    Consensus CDS
    CCDS53423.1
    UniProtKB/Swiss-Prot
    Q8TAS1
    Related
    ENSP00000441226.1, ENST00000545294.5
    Conserved Domains (2) summary
    cd12465
    Location:244331
    RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
    cl21453
    Location:16234
    PKc_like; Protein Kinases, catalytic domain
  2. NM_144624.2NP_653225.2  serine/threonine-protein kinase Kist isoform 3

    See identical proteins and their annotated locations for NP_653225.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL359699, BC026046
    Consensus CDS
    CCDS53424.1
    UniProtKB/Swiss-Prot
    Q8TAS1
    Related
    ENSP00000446416.1, ENST00000538489.5
    Conserved Domains (2) summary
    cd14020
    Location:22308
    STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)
    cl17169
    Location:318341
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_175866.5NP_787062.1  serine/threonine-protein kinase Kist isoform 1

    See identical proteins and their annotated locations for NP_787062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ536197, AL359699
    Consensus CDS
    CCDS1239.1
    UniProtKB/Swiss-Prot
    Q8TAS1
    Related
    ENSP00000420270.1, ENST00000489294.2
    Conserved Domains (2) summary
    cd12465
    Location:318405
    RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
    cd14020
    Location:22308
    STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    162497174..162529631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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