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Cnga3 cyclic nucleotide gated channel alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 12790, updated on 22-Jun-2024

Summary

Official Symbol
Cnga3provided by MGI
Official Full Name
cyclic nucleotide gated channel alpha 3provided by MGI
Primary source
MGI:MGI:1341818
See related
Ensembl:ENSMUSG00000026114 AllianceGenome:MGI:1341818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CNG3; CNG-3
Summary
Enables intracellular cyclic nucleotide activated cation channel activity. Acts upstream of or within retinal cone cell development. Located in photoreceptor outer segment and plasma membrane. Is expressed in eye; gut; and male reproductive gland or organ. Used to study achromatopsia 2. Human ortholog(s) of this gene implicated in achromatopsia 2 and color blindness. Orthologous to human CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Cnga3 in Genome Data Viewer
Location:
1 B; 1 15.46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37257317..37302465)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37218241..37263384)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded rRNA 5S 210 Neighboring gene STARR-seq mESC enhancer starr_00667 Neighboring gene von Willebrand factor A domain containing 3B Neighboring gene STARR-positive B cell enhancer mm9_chr1:37170690-37170991 Neighboring gene predicted gene, 37020 Neighboring gene STARR-seq mESC enhancer starr_00671 Neighboring gene STARR-seq mESC enhancer starr_00672 Neighboring gene STARR-seq mESC enhancer starr_00673 Neighboring gene STARR-seq mESC enhancer starr_00674 Neighboring gene STARR-positive B cell enhancer ABC_E788 Neighboring gene RIKEN cDNA 4930439A04 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37374616-37374799 Neighboring gene inositol polyphosphate-4-phosphatase, type I Neighboring gene STARR-seq mESC enhancer starr_00675 Neighboring gene cytochrome C oxidase assembly factor 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Spontaneous (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cGMP binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intracellularly cAMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intracellularly cGMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in inorganic cation import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to magnesium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within retina development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retinal cone cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
 
located_in cone photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
 
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of transmembrane transporter complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic nucleotide-gated channel alpha-3; cyclic nucleotide-gated cation channel alpha-3
Names
CNG channel alpha-3
CNGgust
cone photoreceptor cGMP-gated channel subunit alpha
cone photoreceptor cGMP-gated channel subunit alpha-3
cyclic nucleotide-gated channel subunit alpha 3
gustatory cyclic nucleotide-gated cation channel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282010.2NP_001268939.1  cyclic nucleotide-gated channel alpha-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC133096
    Consensus CDS
    CCDS78566.1
    UniProtKB/TrEMBL
    A0A0A6YXW9
    Related
    ENSMUSP00000142175.2, ENSMUST00000195272.6
    Conserved Domains (5) summary
    COG0664
    Location:455577
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:461577
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:165387
    Ion_trans; Ion transport protein
    pfam16526
    Location:577647
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    cl18962
    Location:422475
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
  2. NM_001420073.1NP_001407002.1  cyclic nucleotide-gated channel alpha-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC133096
    UniProtKB/TrEMBL
    A0A6H2E2T0
  3. NM_001420074.1NP_001407003.1  cyclic nucleotide-gated channel alpha-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC133096
  4. NM_009918.3NP_034048.1  cyclic nucleotide-gated channel alpha-3 isoform 2

    See identical proteins and their annotated locations for NP_034048.1

    Status: VALIDATED

    Source sequence(s)
    AC133096
    Consensus CDS
    CCDS14890.1
    UniProtKB/Swiss-Prot
    Q8CFV6, Q9JJZ8, Q9WV01
    Related
    ENSMUSP00000027288.8, ENSMUST00000027288.10
    Conserved Domains (3) summary
    cd00038
    Location:423539
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:109349
    Ion_trans; Ion transport protein
    pfam16526
    Location:539608
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37257317..37302465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313745.3XP_017169234.1  cyclic nucleotide-gated cation channel alpha-3 isoform X1

    UniProtKB/Swiss-Prot
    Q8CFV6, Q9JJZ8, Q9WV01
    Related
    ENSMUSP00000142075.2, ENSMUST00000194195.6
    Conserved Domains (3) summary
    cd00038
    Location:423539
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:109349
    Ion_trans; Ion transport protein
    pfam16526
    Location:539608
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  2. XM_017313748.3XP_017169237.1  cyclic nucleotide-gated cation channel alpha-3 isoform X2

    UniProtKB/TrEMBL
    A0A6H2E2T0
    Conserved Domains (3) summary
    cd00038
    Location:422538
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:108348
    Ion_trans; Ion transport protein
    pfam16526
    Location:538607
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  3. XM_036157115.1XP_036013008.1  cyclic nucleotide-gated cation channel alpha-3 isoform X1

    UniProtKB/Swiss-Prot
    Q8CFV6, Q9JJZ8, Q9WV01
    Conserved Domains (3) summary
    cd00038
    Location:423539
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:109349
    Ion_trans; Ion transport protein
    pfam16526
    Location:539608
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels