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Cnga1 cyclic nucleotide gated channel alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 12788, updated on 22-Jun-2024

Summary

Official Symbol
Cnga1provided by MGI
Official Full Name
cyclic nucleotide gated channel alpha 1provided by MGI
Primary source
MGI:MGI:88436
See related
Ensembl:ENSMUSG00000067220 AllianceGenome:MGI:88436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cncg
Summary
Predicted to enable cGMP binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Predicted to be involved in membrane depolarization and regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within ion transport and visual perception. Located in photoreceptor outer segment membrane. Is expressed in photoreceptor layer outer segment; retina; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Cnga1 in Genome Data Viewer
Location:
5 C3.2; 5 38.44 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72761039..72800095, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72603696..72642752, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), pseudogene Neighboring gene zygote arrest 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73025974-73026235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73027370-73027613 Neighboring gene predicted gene 5297 Neighboring gene NIPA-like domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3582 Neighboring gene TXK tyrosine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
 
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cGMP binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intracellularly cGMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of intracellular cyclic nucleotide activated cation channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic nucleotide-gated channel alpha-1; cGMP-gated cation channel alpha-1
Names
CNG channel alpha-1
CNG-1
CNG1
cyclic nucleotide gated channel, cGMP gated
cyclic nucleotide-gated cation channel 1
cyclic nucleotide-gated channel, photoreceptor
rod photoreceptor cGMP-gated cation channel subunit alpha
rod photoreceptor cGMP-gated channel subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007723.2NP_031749.2  cyclic nucleotide-gated channel alpha-1

    See identical proteins and their annotated locations for NP_031749.2

    Status: VALIDATED

    Source sequence(s)
    AC122733, BI738168, BI871897, CO423854, CX564336
    Consensus CDS
    CCDS19333.1
    UniProtKB/Swiss-Prot
    B9EJ09, P29974, Q60776
    Related
    ENSMUSP00000084464.6, ENSMUST00000087213.12
    Conserved Domains (4) summary
    COG0664
    Location:465621
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:471587
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:179399
    Ion_trans; Ion transport protein
    pfam16526
    Location:587657
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    72761039..72800095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503709.1XP_006503772.1  cGMP-gated cation channel alpha-1 isoform X1

    Conserved Domains (3) summary
    cd00038
    Location:486602
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:172414
    Ion_trans; Ion transport protein
    pfam16526
    Location:602671
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels