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Cnbp cellular nucleic acid binding protein [ Mus musculus (house mouse) ]

Gene ID: 12785, updated on 8-Feb-2024

Summary

Official Symbol
Cnbpprovided by MGI
Official Full Name
cellular nucleic acid binding proteinprovided by MGI
Primary source
MGI:MGI:88431
See related
Ensembl:ENSMUSG00000030057 AllianceGenome:MGI:88431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf9; Cnbp1
Summary
Predicted to enable nucleic acid binding activity and translation regulator activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of transcription by RNA polymerase II. Located in cytosol; endoplasmic reticulum; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 105.5), liver E14 (RPKM 104.7) and 28 other tissues See more
Orthologs
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Genomic context

See Cnbp in Genome Data Viewer
Location:
6 D1; 6 39.13 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87819597..87828088, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87842615..87851106, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16566 Neighboring gene RAB43, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E10388 Neighboring gene STARR-positive B cell enhancer ABC_E11324 Neighboring gene STARR-seq mESC enhancer starr_16567 Neighboring gene ISY1 splicing factor homolog Neighboring gene STARR-seq mESC enhancer starr_16568 Neighboring gene STARR-positive B cell enhancer ABC_E2793 Neighboring gene coatomer protein complex, subunit gamma 1 Neighboring gene STARR-positive B cell enhancer ABC_E1704 Neighboring gene 5-hydroxymethylcytosine (hmC) binding, ES cell specific Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1)  1 citation
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CCHC-type zinc finger nucleic acid binding protein
Names
cellular nucleic acid binding protein 1
zinc finger protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109745.1NP_001103215.1  CCHC-type zinc finger nucleic acid binding protein isoform 2

    See identical proteins and their annotated locations for NP_001103215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AK078427, AK144740, AK159810, CJ088264
    UniProtKB/TrEMBL
    Q3U5V2
    Conserved Domains (1) summary
    PTZ00368
    Location:47165
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  2. NM_001109746.1NP_001103216.1  CCHC-type zinc finger nucleic acid binding protein isoform 3

    See identical proteins and their annotated locations for NP_001103216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has two alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (3) differs in the middle region and has identical N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AK144740, AK151961, CJ088264
    Consensus CDS
    CCDS85092.1
    UniProtKB/TrEMBL
    Q3U935
    Related
    ENSMUSP00000109249.3, ENSMUST00000113619.8
    Conserved Domains (1) summary
    PTZ00368
    Location:47164
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  3. NM_001347325.1NP_001334254.1  CCHC-type zinc finger nucleic acid binding protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (4) lacks one amino acid, as compared to isoform 1.
    Source sequence(s)
    AK075760, AK144740, AK147157, CJ088264
    Consensus CDS
    CCDS85091.1
    UniProtKB/TrEMBL
    D3YYF6, Q3ULK8
    Related
    ENSMUSP00000145274.2, ENSMUST00000204653.3
    Conserved Domains (1) summary
    PTZ00368
    Location:54171
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  4. NM_001355195.1NP_001342124.1  CCHC-type zinc finger nucleic acid binding protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (5) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1. Isoforms 2 and 5 are the same length but have distinct sequences.
    Source sequence(s)
    AK144740, AK147157, CJ088264
    Consensus CDS
    CCDS90085.1
    UniProtKB/TrEMBL
    A0A0N4SVS6
    Related
    ENSMUSP00000145227.2, ENSMUST00000204890.3
    Conserved Domains (1) summary
    PTZ00368
    Location:48165
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  5. NM_013493.3NP_038521.1  CCHC-type zinc finger nucleic acid binding protein isoform 1

    See identical proteins and their annotated locations for NP_038521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK144740, BC058723, CJ088264
    Consensus CDS
    CCDS51841.1
    UniProtKB/Swiss-Prot
    P53996, Q80Y06, Q8BP23
    UniProtKB/TrEMBL
    Q5QJQ9
    Related
    ENSMUSP00000032138.9, ENSMUST00000032138.15
    Conserved Domains (1) summary
    PTZ00368
    Location:54172
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87819597..87828088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)