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ARL8A ADP ribosylation factor like GTPase 8A [ Homo sapiens (human) ]

Gene ID: 127829, updated on 6-Jan-2019

Summary

Official Symbol
ARL8Aprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 8Aprovided by HGNC
Primary source
HGNC:HGNC:25192
See related
Ensembl:ENSG00000143862 MIM:616597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIE2; ARL10B
Expression
Ubiquitous expression in brain (RPKM 56.4), bone marrow (RPKM 24.8) and 25 other tissues See more
Orthologs

Genomic context

See ARL8A in Genome Data Viewer
Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (202133404..202144743, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202102532..202113871, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371684 Neighboring gene cysteine rich protein 1 pseudogene 3 Neighboring gene uncharacterized LOC105371683 Neighboring gene G protein-coupled receptor 37 like 1 Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene protein tyrosine phosphatase, receptor type V, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45195

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
alpha-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
beta-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterograde axonal transport IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
azurophil granule membrane TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane HDA PubMed 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 8A
Names
ADP-ribosylation factor-like 10B
ADP-ribosylation factor-like 8A
novel small G protein indispensable for equal chromosome segregation 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256129.1NP_001243058.1  ADP-ribosylation factor-like protein 8A isoform 2

    See identical proteins and their annotated locations for NP_001243058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK127138, AW090198, BC069053, BG876867, BP325806
    Consensus CDS
    CCDS73004.1
    UniProtKB/Swiss-Prot
    Q96BM9
    UniProtKB/TrEMBL
    A0A087X2J2
    Related
    ENSP00000485023.1, ENST00000614750.1
    Conserved Domains (1) summary
    cd04159
    Location:22128
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases
  2. NM_138795.4NP_620150.1  ADP-ribosylation factor-like protein 8A isoform 1

    See identical proteins and their annotated locations for NP_620150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW090198, BC015408, BC069053, BP325806
    Consensus CDS
    CCDS1421.1
    UniProtKB/Swiss-Prot
    Q96BM9
    UniProtKB/TrEMBL
    A0A024R977
    Related
    ENSP00000272217.2, ENST00000272217.6
    Conserved Domains (1) summary
    cd04159
    Location:22180
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    202133404..202144743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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