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Ccr5 chemokine (C-C motif) receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 12774, updated on 20-Jul-2021

Summary

Official Symbol
Ccr5provided by MGI
Official Full Name
chemokine (C-C motif) receptor 5provided by MGI
Primary source
MGI:MGI:107182
See related
Ensembl:ENSMUSG00000079227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AM4-7; CD195; Cmkbr; Cmkbr5
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 2.2), mammary gland adult (RPKM 2.1) and 27 other tissues See more
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Genomic context

See Ccr5 in Genome Data Viewer
Location:
9 F4; 9 75.05 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123921557..123934153)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (124121543..124127183)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (124036282..124041922)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) receptor 3 Neighboring gene chemokine (C-C motif) receptor 2 Neighboring gene predicted gene, 39469 Neighboring gene RIKEN cDNA 2010315B03 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables C-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables C-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine (C-C motif) ligand 5 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine (C-C motif) ligand 5 binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fever generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-C chemokine receptor type 5
Names
C-C CKR-5
CC-CKR-5
CCR-5
MIP-1 alpha receptor
chemokine (C-C) receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009917.5NP_034047.2  C-C chemokine receptor type 5

    See identical proteins and their annotated locations for NP_034047.2

    Status: VALIDATED

    Source sequence(s)
    AK155628, BC103574, BG091923, BY198155
    Consensus CDS
    CCDS40821.1
    UniProtKB/Swiss-Prot
    P51682
    Related
    ENSMUSP00000107069.2, ENSMUST00000111442.3
    Conserved Domains (1) summary
    cd15184
    Location:33310
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    123921557..123934153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154589.1XP_036010482.1  C-C chemokine receptor type 5 isoform X1

    Conserved Domains (1) summary
    cd15184
    Location:33310
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
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