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Cmah cytidine monophospho-N-acetylneuraminic acid hydroxylase [ Mus musculus (house mouse) ]

Gene ID: 12763, updated on 23-Jun-2021

Summary

Official Symbol
Cmahprovided by MGI
Official Full Name
cytidine monophospho-N-acetylneuraminic acid hydroxylaseprovided by MGI
Primary source
MGI:MGI:103227
See related
Ensembl:ENSMUSG00000016756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in spleen adult (RPKM 1.9), liver adult (RPKM 1.7) and 14 other tissues See more
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Genomic context

See Cmah in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24511387..24661272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24327404..24477289)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (24419289..24569154)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23340 Neighboring gene ribosomal protein L27a pseudogene Neighboring gene predicted gene 11342 Neighboring gene predicted gene, 22013 Neighboring gene RHO family interacting cell polarization regulator 2 Neighboring gene X-linked lymphocyte-regulated 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables CMP-N-acetylneuraminate monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables CMP-N-acetylneuraminate monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytidine monophosphate-N-acetylneuraminic acid hydroxylase
Names
CMP-N-acetylneuraminate monooxygenase
CMP-N-acetylneuraminic acid hydroxylase
CMP-Neu5Ac hydroxylase
CMP-NeuAc hydroxylase
NP_001104580.1
NP_001271448.1
NP_001271449.1
NP_031743.3
XP_011242567.1
XP_011242568.1
XP_011242576.1
XP_036013735.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111110.2NP_001104580.1  cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform a

    See identical proteins and their annotated locations for NP_001104580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 encode the same protein (isoform a).
    Source sequence(s)
    AA122526, AB061276, AK083394, AL589744, AL590864
    Consensus CDS
    CCDS26376.1
    UniProtKB/Swiss-Prot
    Q61419
    Related
    ENSMUSP00000129007.2, ENSMUST00000167746.8
    Conserved Domains (3) summary
    COG2220
    Location:135252
    UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
    cd03473
    Location:6112
    Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...
    cl23716
    Location:138208
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  2. NM_001284519.1NP_001271448.1  cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform a

    See identical proteins and their annotated locations for NP_001271448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA122526, AB061277, AK083394, AL589744, AL590864
    Consensus CDS
    CCDS26376.1
    UniProtKB/Swiss-Prot
    Q61419
    Related
    ENSMUSP00000061045.6, ENSMUST00000050859.13
    Conserved Domains (3) summary
    COG2220
    Location:135252
    UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
    cd03473
    Location:6112
    Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...
    cl23716
    Location:138208
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  3. NM_001284520.1NP_001271449.1  cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform b

    See identical proteins and their annotated locations for NP_001271449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 3. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AA122526, AK083394, AL589744, BC055079, CA577904
    UniProtKB/Swiss-Prot
    Q61419
    Related
    ENSMUSP00000153248.2, ENSMUST00000224819.2
    Conserved Domains (3) summary
    COG2220
    Location:135252
    UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
    cd03473
    Location:6112
    Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...
    cl23716
    Location:138208
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  4. NM_007717.5NP_031743.3  cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform a

    See identical proteins and their annotated locations for NP_031743.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 encode the same protein (isoform a).
    Source sequence(s)
    AA122526, AK083394, AL589744, BC055079, CA577904
    Consensus CDS
    CCDS26376.1
    UniProtKB/Swiss-Prot
    Q61419
    Related
    ENSMUSP00000153495.2, ENSMUST00000224657.2
    Conserved Domains (3) summary
    COG2220
    Location:135252
    UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
    cd03473
    Location:6112
    Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...
    cl23716
    Location:138208
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    24511387..24661272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157842.1XP_036013735.1  cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform X3

  2. XM_011244265.4XP_011242567.1  cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform X1

    See identical proteins and their annotated locations for XP_011242567.1

    Conserved Domains (2) summary
    COG2220
    Location:138255
    UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
    cd03473
    Location:9115
    Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...
  3. XM_011244266.4XP_011242568.1  cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform X1

    See identical proteins and their annotated locations for XP_011242568.1

    Conserved Domains (2) summary
    COG2220
    Location:138255
    UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
    cd03473
    Location:9115
    Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...
  4. XM_011244274.4XP_011242576.1  cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform X2

    Conserved Domains (2) summary
    COG2220
    Location:138255
    UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
    cd03473
    Location:9115
    Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...
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