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DNAH14 dynein axonemal heavy chain 14 [ Homo sapiens (human) ]

Gene ID: 127602, updated on 25-Jan-2022

Summary

Official Symbol
DNAH14provided by HGNC
Official Full Name
dynein axonemal heavy chain 14provided by HGNC
Primary source
HGNC:HGNC:2945
See related
Ensembl:ENSG00000185842 MIM:603341; AllianceGenome:HGNC:2945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HL18; HL-18; C1orf67; Dnahc14
Summary
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.3) and 6 other tissues See more
Orthologs
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Genomic context

See DNAH14 in Genome Data Viewer
Location:
1q42.12
Exon count:
90
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (224928422..225399292)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (225117356..225586988)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2813 Neighboring gene uncharacterized LOC105373108 Neighboring gene uncharacterized LOC105373109 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11936 Neighboring gene lamin B receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27277, MGC51214, MGC149665, MGC149666, DKFZp781B1548

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium-dependent cell motility IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of axonemal dynein complex IEA
Inferred from Electronic Annotation
more info
 
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein axonemal heavy chain 14
Names
axonemal beta dynein heavy chain 14
ciliary dynein heavy chain 14
dynein heavy chain 14, axonemal
dynein, axonemal, heavy polypeptide 14
NP_001138626.1
NP_001336840.1
NP_001336841.1
NP_001354408.1
NP_001354410.1
NP_659426.2
XP_006711798.1
XP_011542360.1
XP_011542361.1
XP_011542363.1
XP_011542364.1
XP_011542365.1
XP_011542366.1
XP_011542367.1
XP_011542368.1
XP_011542369.1
XP_011542371.1
XP_011542372.1
XP_011542373.1
XP_011542374.1
XP_011542375.1
XP_011542376.1
XP_011542378.1
XP_011542381.1
XP_011542383.1
XP_016855784.1
XP_016855785.1
XP_016855786.1
XP_016855787.1
XP_016855788.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053088.1 RefSeqGene

    Range
    6254..101183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145154.3NP_001138626.1  dynein axonemal heavy chain 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL590547, BC042869, BC119716
    Consensus CDS
    CCDS44322.1
    UniProtKB/Swiss-Prot
    Q0VDD8
    Related
    ENSP00000383737.3, ENST00000400952.7
  2. NM_001349911.2NP_001336840.1  dynein axonemal heavy chain 14 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093560, AL590547
    Consensus CDS
    CCDS86053.1
    Related
    ENSP00000355814.1, ENST00000366849.5
  3. NM_001349912.2NP_001336841.1  dynein axonemal heavy chain 14 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093560
  4. NM_001367479.1NP_001354408.1  dynein axonemal heavy chain 14 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC092811, AC093560, AL162738, AL357912, AL590547, AL596134, AL645769
    Related
    ENSP00000508305.1, ENST00000682510.1
  5. NM_001367481.1NP_001354410.1  dynein axonemal heavy chain 14 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC093560
  6. NM_144989.3NP_659426.2  dynein axonemal heavy chain 14 isoform 3

    See identical proteins and their annotated locations for NP_659426.2

    Status: VALIDATED

    Source sequence(s)
    AC093560, BC017415, BC119716, CA389321, DB443048
    Consensus CDS
    CCDS41472.1
    UniProtKB/Swiss-Prot
    Q0VDD8
    Related
    ENSP00000355815.3, ENST00000366850.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    224928422..225399292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544071.2XP_011542373.1  dynein axonemal heavy chain 14 isoform X17

    Conserved Domains (5) summary
    pfam03028
    Location:36024428
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:8161219
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:28273161
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:31873402
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:13511578
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011544062.2XP_011542364.1  dynein axonemal heavy chain 14 isoform X9

    Conserved Domains (5) summary
    pfam03028
    Location:37784552
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30033337
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33633578
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011544067.2XP_011542369.1  dynein axonemal heavy chain 14 isoform X14

    Conserved Domains (5) summary
    pfam03028
    Location:37784528
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30033337
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33633578
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_017000296.1XP_016855785.1  dynein axonemal heavy chain 14 isoform X6

  5. XM_011544065.2XP_011542367.1  dynein axonemal heavy chain 14 isoform X12

    Conserved Domains (5) summary
    pfam03028
    Location:37144540
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:29393273
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:32993514
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011544069.2XP_011542371.1  dynein axonemal heavy chain 14 isoform X15

    Conserved Domains (5) summary
    pfam03028
    Location:36604486
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:28853219
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:32453460
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_006711735.3XP_006711798.1  dynein axonemal heavy chain 14 isoform X5

    Conserved Domains (5) summary
    pfam03028
    Location:37474573
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:29723306
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33323547
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_011544064.2XP_011542366.1  dynein axonemal heavy chain 14 isoform X11

    Conserved Domains (5) summary
    pfam03028
    Location:37224548
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:29473281
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33073522
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_011544058.2XP_011542360.1  dynein axonemal heavy chain 14 isoform X2

    Conserved Domains (5) summary
    pfam03028
    Location:37774603
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30023336
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33623577
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. XM_011544063.2XP_011542365.1  dynein axonemal heavy chain 14 isoform X10

    Conserved Domains (5) summary
    pfam03028
    Location:37254551
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:29503284
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33103525
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  11. XM_017000297.1XP_016855786.1  dynein axonemal heavy chain 14 isoform X8

  12. XM_011544059.2XP_011542361.1  dynein axonemal heavy chain 14 isoform X3

    Conserved Domains (5) summary
    pfam03028
    Location:37624588
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:29873321
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33473562
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  13. XM_011544066.2XP_011542368.1  dynein axonemal heavy chain 14 isoform X13

    Conserved Domains (5) summary
    pfam03028
    Location:37064532
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:29313265
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:32913506
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271754
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  14. XM_011544061.2XP_011542363.1  dynein axonemal heavy chain 14 isoform X7

    Conserved Domains (5) summary
    pfam03028
    Location:37434569
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:9921395
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:29683302
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33283543
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:15271719
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  15. XM_017000295.1XP_016855784.1  dynein axonemal heavy chain 14 isoform X4

  16. XM_011544070.2XP_011542372.1  dynein axonemal heavy chain 14 isoform X16

    Conserved Domains (5) summary
    pfam03028
    Location:36524478
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:8661269
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:28773211
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:32373452
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:14011628
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  17. XM_011544072.2XP_011542374.1  dynein axonemal heavy chain 14 isoform X18

    Conserved Domains (5) summary
    pfam03028
    Location:33394165
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:553956
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:25642898
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:29243139
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:10881315
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  18. XM_017000298.1XP_016855787.1  dynein axonemal heavy chain 14 isoform X20

  19. XM_011544073.2XP_011542375.1  dynein axonemal heavy chain 14 isoform X19

    Conserved Domains (5) summary
    pfam03028
    Location:31944020
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:408811
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:24192753
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:27792994
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:9431170
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  20. XM_011544074.2XP_011542376.1  dynein axonemal heavy chain 14 isoform X21

    Conserved Domains (5) summary
    pfam03028
    Location:29843810
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:198601
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:22092543
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:25692784
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:733960
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  21. XM_011544076.1XP_011542378.1  dynein axonemal heavy chain 14 isoform X22

    Conserved Domains (5) summary
    pfam03028
    Location:27273553
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:1344
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:19522286
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:23122527
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:476703
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  22. XM_011544079.1XP_011542381.1  dynein axonemal heavy chain 14 isoform X24

    Conserved Domains (4) summary
    pfam03028
    Location:22273053
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam12777
    Location:14521786
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:18122027
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:2203
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  23. XM_017000299.1XP_016855788.1  dynein axonemal heavy chain 14 isoform X23

  24. XM_011544081.1XP_011542383.1  dynein axonemal heavy chain 14 isoform X25

    Conserved Domains (4) summary
    pfam03028
    Location:19642790
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam12777
    Location:11891523
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:15491764
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:9161177
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_001736974.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001373.1: Suppressed sequence

    Description
    NM_001373.1: This RefSeq was removed because there is insufficient support for the transcript and protein.
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