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Cldn4 claudin 4 [ Mus musculus (house mouse) ]

Gene ID: 12740, updated on 12-May-2024

Summary

Official Symbol
Cldn4provided by MGI
Official Full Name
claudin 4provided by MGI
Primary source
MGI:MGI:1313314
See related
Ensembl:ENSMUSG00000047501 AllianceGenome:MGI:1313314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cep-r; Cpetr; Cpetr1
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers. [provided by RefSeq, Aug 2010]
Orthologs
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Genomic context

See Cldn4 in Genome Data Viewer
Location:
5 G2; 5 74.9 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134973977..134975788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134945123..134946934, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene claudin 13 Neighboring gene STARR-seq mESC enhancer starr_14554 Neighboring gene RIKEN cDNA 9030607J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1310 Neighboring gene STARR-seq mESC enhancer starr_14556 Neighboring gene methyltransferase like 27 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135417798-135418057 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135427401-135427609 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135442157-135442340 Neighboring gene STARR-seq mESC enhancer starr_14561 Neighboring gene Williams Beuren syndrome chromosome region 25 (human) Neighboring gene claudin 3 Neighboring gene predicted gene, 57747

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in renal absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
claudin-4
Names
CPE-R
CPE-receptor
clostridium perfringens enterotoxin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009903.2NP_034033.1  claudin-4

    See identical proteins and their annotated locations for NP_034033.1

    Status: REVIEWED

    Source sequence(s)
    AK145152, BC132378, BQ031935
    Consensus CDS
    CCDS19728.1
    UniProtKB/Swiss-Prot
    O35054
    UniProtKB/TrEMBL
    Q3UM35
    Related
    ENSMUSP00000053420.3, ENSMUST00000051401.4
    Conserved Domains (1) summary
    cl21598
    Location:4170
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134973977..134975788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)