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PRXL2B peroxiredoxin like 2B [ Homo sapiens (human) ]

Gene ID: 127281, updated on 7-Jun-2020

Summary

Official Symbol
PRXL2Bprovided by HGNC
Official Full Name
peroxiredoxin like 2Bprovided by HGNC
Primary source
HGNC:HGNC:28390
See related
Ensembl:ENSG00000157870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf93; FAM213B
Expression
Ubiquitous expression in duodenum (RPKM 15.1), small intestine (RPKM 14.9) and 24 other tissues See more
Orthologs

Genomic context

See PRXL2B in Genome Data Viewer
Location:
1p36.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (2586523..2591469)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2517899..2522908)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNFRSF14 antisense RNA 1 Neighboring gene uncharacterized LOC100996583 Neighboring gene TNF receptor superfamily member 14 Neighboring gene membrane metalloendopeptidase like 1 Neighboring gene MMEL1 antisense RNA 1 Neighboring gene tetratricopeptide repeat domain 34 Neighboring gene uncharacterized LOC105378603 Neighboring gene uncharacterized LOC105378602

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26818, DKFZp547M123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
prostaglandin-F synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular exosome HDA PubMed 
myelin sheath ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
prostamide/prostaglandin F synthase
Names
family with sequence similarity 213 member B
prostamide/PG F synthase
prostamide/PGF synthase
thioredoxin-type PGF synthase
NP_001182665.4
NP_001182666.4
NP_001182667.4
NP_001182669.4
NP_001182670.4
NP_689584.5
XP_006710417.1
XP_011538967.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195736.3NP_001182665.4  prostamide/prostaglandin F synthase isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
    Source sequence(s)
    AK057027, AK075273, BM976058, DC351872
    Consensus CDS
    CCDS72690.1
    Related
    ENSP00000413218.3, ENST00000444521.6
    Conserved Domains (1) summary
    cd02970
    Location:18185
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  2. NM_001195737.3NP_001182666.4  prostamide/prostaglandin F synthase isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses three different splice sites in the coding region, compared to variant 1. The resulting protein (isoform c) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK303504, BM976058, DC351872
    Related
    ENST00000484099.5
    Conserved Domains (1) summary
    cd02970
    Location:18123
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  3. NM_001195738.3NP_001182667.4  prostamide/prostaglandin F synthase isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two different splice sites in the coding region which changes the reading frame, compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus when it is compared to isoform a.
    Source sequence(s)
    AK075273, BM976058, DC351872
    Related
    ENSP00000367684.2, ENST00000378427.6
    Conserved Domains (1) summary
    cd02970
    Location:18154
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  4. NM_001195740.3NP_001182669.4  prostamide/prostaglandin F synthase isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK316243, BM976058, DC351872
    Consensus CDS
    CCDS72691.1
    Related
    ENSP00000367682.6, ENST00000378425.9
    Conserved Domains (1) summary
    cd02970
    Location:18123
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  5. NM_001195741.3NP_001182670.4  prostamide/prostaglandin F synthase isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK298926, BM976058, DC351872
    Consensus CDS
    CCDS55564.1
    Related
    ENSP00000443605.2, ENST00000537325.6
    Conserved Domains (1) summary
    cd02970
    Location:18123
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  6. NM_152371.5NP_689584.5  prostamide/prostaglandin F synthase isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in an internal coding region exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
    Source sequence(s)
    AF425266, AK075273, BC022547, BM976058, DC351872
    Consensus CDS
    CCDS44.2
    Related
    ENSP00000394405.3, ENST00000419916.7
    Conserved Domains (1) summary
    cd02970
    Location:18167
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RNA

  1. NR_036637.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate 5'-most exon and an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK075273, BM976058, BQ709693, DA495138
  2. NR_036638.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 5'-most exon and two alternate internal splice sites, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK075273, BI908668, BM976058, DA292832

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    2586523..2591469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540665.1XP_011538967.1  prostamide/prostaglandin F synthase isoform X2

    See identical proteins and their annotated locations for XP_011538967.1

    Conserved Domains (1) summary
    cd02970
    Location:48140
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  2. XM_006710354.3XP_006710417.1  prostamide/prostaglandin F synthase isoform X1

    See identical proteins and their annotated locations for XP_006710417.1

    Conserved Domains (1) summary
    cd02970
    Location:48153
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187515.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    137713..142658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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