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OR2T12 olfactory receptor family 2 subfamily T member 12 [ Homo sapiens (human) ]

Gene ID: 127064, updated on 24-Sep-2022

Summary

Official Symbol
OR2T12provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily T member 12provided by HGNC
Primary source
HGNC:HGNC:19592
See related
Ensembl:ENSG00000177201 AllianceGenome:HGNC:19592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR1-57
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
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Genomic context

See OR2T12 in Genome Data Viewer
Location:
1q44
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248290139..248303424, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247716221..247729507, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248453441..248466726, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily M member 4 Neighboring gene olfactory receptor family 2 subfamily T member 33 Neighboring gene olfactory receptor family 2 subfamily M member 7 Neighboring gene olfactory receptor family 14 subfamily C member 36

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 2T12
Names
novel 7 transmembrane receptor (rhodopsin family) protein
olfactory receptor OR1-57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004692.2NP_001004692.1  olfactory receptor 2T12 isoform 1

    See identical proteins and their annotated locations for NP_001004692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the allele encoded by the GRCh38 reference genome and encodes the longer isoform (1).
    Source sequence(s)
    AL450303
    Consensus CDS
    CCDS31110.1
    UniProtKB/Swiss-Prot
    Q8NG77
    Related
    ENSP00000493000.1, ENST00000641276.1
    Conserved Domains (1) summary
    cd15421
    Location:23299
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001412178.1NP_001399107.1  olfactory receptor 2T12 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (2) has a shorter N-terminus because it uses a downstream start codon, compared to isoform 1.
    Source sequence(s)
    CP068277

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    248290139..248303424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    247716221..247729507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)