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LYPLAL1 lysophospholipase like 1 [ Homo sapiens (human) ]

Gene ID: 127018, updated on 16-Oct-2021

Summary

Official Symbol
LYPLAL1provided by HGNC
Official Full Name
lysophospholipase like 1provided by HGNC
Primary source
HGNC:HGNC:20440
See related
Ensembl:ENSG00000143353 MIM:616548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Q96AV0
Expression
Ubiquitous expression in kidney (RPKM 3.2), heart (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

See LYPLAL1 in Genome Data Viewer
Location:
1q41
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (219173850..219445121)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (219347220..219386200)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1710 Neighboring gene LYPLAL1 divergent transcript Neighboring gene ribosomal modification protein rimK like family member B pseudogene 2 Neighboring gene uncharacterized LOC107984018 Neighboring gene LYPLAL1 antisense RNA 1 Neighboring gene uncharacterized LOC107985272 Neighboring gene zinc finger CCCH-type containing 11B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
GeneReviews: Not available
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
GeneReviews: Not available
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
GeneReviews: Not available
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99730, KIAA1238

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysophospholipase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
lysophospholipase-like protein 1
NP_001287698.1
NP_001287699.1
NP_001287700.1
NP_001287701.1
NP_001337557.1
NP_001337558.1
NP_620149.2
XP_011507485.1
XP_016855760.1
XP_016855761.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300769.2NP_001287698.1  lysophospholipase-like protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK309689, AL360093, BC016711, BF115063
    UniProtKB/Swiss-Prot
    Q5VWZ2
    Related
    ENST00000474379.5
    Conserved Domains (1) summary
    cl21494
    Location:13171
    Abhydrolase; alpha/beta hydrolases
  2. NM_001300770.2NP_001287699.1  lysophospholipase-like protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AA424278, AL360093, AY341430, BC016711, BF115063, HY106571
    Consensus CDS
    CCDS73032.1
    UniProtKB/Swiss-Prot
    Q5VWZ2
    Related
    ENSP00000355894.3, ENST00000366927.3
    Conserved Domains (2) summary
    COG0596
    Location:16134
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:13206
    Abhydrolase; alpha/beta hydrolases
  3. NM_001300771.2NP_001287700.1  lysophospholipase-like protein 1 isoform d

    See identical proteins and their annotated locations for NP_001287700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' reading frame, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (d).
    Source sequence(s)
    AA424278, AL360093, BC016711, BF115063, CB851909
    UniProtKB/Swiss-Prot
    Q5VWZ2
    Related
    ENST00000483635.5
    Conserved Domains (1) summary
    cl21494
    Location:13184
    Abhydrolase; alpha/beta hydrolases
  4. NM_001300772.2NP_001287701.1  lysophospholipase-like protein 1 isoform d

    See identical proteins and their annotated locations for NP_001287701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' reading frame, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (d).
    Source sequence(s)
    AA417842, AA424278, AL360093, AW967835, BC016711, BF115063, BX282451
    UniProtKB/Swiss-Prot
    Q5VWZ2
    Conserved Domains (1) summary
    cl21494
    Location:13184
    Abhydrolase; alpha/beta hydrolases
  5. NM_001350628.2NP_001337557.1  lysophospholipase-like protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (e) is longer than isoform a.
    Source sequence(s)
    AA424278, AL360093, BC016711, BF115063, BI830985, HY106571
    Related
    ENST00000463964.5
    Conserved Domains (1) summary
    cl21494
    Location:13231
    Abhydrolase; alpha/beta hydrolases
  6. NM_001350629.2NP_001337558.1  lysophospholipase-like protein 1 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (f) is shorter than isoform a
    Source sequence(s)
    AA424278, AL360093, BC016711, BF115063, BI830985, HY106571
    Related
    ENST00000477938.5
    Conserved Domains (1) summary
    cl21494
    Location:13215
    Abhydrolase; alpha/beta hydrolases
  7. NM_138794.5NP_620149.2  lysophospholipase-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_620149.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AA424278, AL360093, BC016711, BF115063, HY106571
    Consensus CDS
    CCDS1522.1
    UniProtKB/Swiss-Prot
    Q5VWZ2
    Related
    ENSP00000355895.5, ENST00000366928.10
    Conserved Domains (2) summary
    COG0596
    Location:16150
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:13222
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    219173850..219445121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509183.2XP_011507485.1  lysophospholipase-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011507485.1

    Conserved Domains (1) summary
    cl21494
    Location:13193
    Abhydrolase; alpha/beta hydrolases
  2. XM_017000271.2XP_016855760.1  lysophospholipase-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:13231
    Abhydrolase; alpha/beta hydrolases
  3. XM_017000272.1XP_016855761.1  lysophospholipase-like protein 1 isoform X3

    Conserved Domains (1) summary
    cl21494
    Location:50171
    Abhydrolase; alpha/beta hydrolases

RNA

  1. XR_001736967.2 RNA Sequence

  2. XR_002959345.1 RNA Sequence

  3. XR_001736963.2 RNA Sequence

  4. XR_001736968.2 RNA Sequence

  5. XR_001736964.2 RNA Sequence

  6. XR_001736965.2 RNA Sequence

  7. XR_001736966.2 RNA Sequence

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