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CNR2 cannabinoid receptor 2 [ Homo sapiens (human) ]

Gene ID: 1269, updated on 23-Jul-2018

Summary

Official Symbol
CNR2provided by HGNC
Official Full Name
cannabinoid receptor 2provided by HGNC
Primary source
HGNC:HGNC:2160
See related
Ensembl:ENSG00000188822 MIM:605051; Vega:OTTHUMG00000013892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CB2; CX5; CB-2
Summary
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 3.7), spleen (RPKM 3.4) and 4 other tissues See more
Orthologs

Genomic context

See CNR2 in Genome Data Viewer
Location:
1p36.11
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (23873075..23913327, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24197005..24285549, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376861 Neighboring gene alpha-L-fucosidase 1 Neighboring gene BTB domain containing 6 pseudogene 1 Neighboring gene uncharacterized LOC107984929 Neighboring gene microRNA 378f Neighboring gene proline rich nuclear receptor coactivator 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Upregulation of the human proteins CCL2, CX3CL1, IL-1beta, and CXCL10 by HIV-1 gp120 involves CB2 receptor in mesencephalic neuronal/glial culture model PubMed
env CB1 or CB2 receptor agonists significantly inhibit HIV-1 gp120-induced decrease proliferation and increase apoptosis of human neural progenitor cells (hNPCs), indicating that CB1 or CB2 receptors are required for the effects of gp120 on hNPCs PubMed
env HIV-1 gp120-induced synapse loss is inhibited by activation of CB2 receptor PubMed
Tat tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed
tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat upregulates the expression of CB1 and CB2 cannabinoid receptors in retinal cells, which is suppressed by endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol PubMed
tat CB(2) cannabinoid receptor 2 is involved in HIV-1 Tat-mediated macrophage migration PubMed
tat HIV-1 Tat-mediated activation of the CB2R leads to altered expression and compartmentation of the beta-chemokine receptor CCR-3 PubMed
capsid gag Monocyte-derived macrophages treated during differentiation with a CB2 specific agonist show decrease in p24 levels PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Small Ligand GPCRs, organism-specific biosystem (from WikiPathways)
    Small Ligand GPCRs, organism-specific biosystem
    Small Ligand GPCRs

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cannabinoid receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
cannabinoid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of action potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mast cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
dendrite IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cannabinoid receptor 2
Names
cannabinoid receptor 2 (macrophage)
testis-dominant CNR2 isoform CB2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001841.2NP_001832.1  cannabinoid receptor 2

    See identical proteins and their annotated locations for NP_001832.1

    Status: REVIEWED

    Source sequence(s)
    AL590609, BC069722, X74328
    Consensus CDS
    CCDS245.1
    UniProtKB/Swiss-Prot
    P34972
    UniProtKB/TrEMBL
    A0A024RAH7
    Related
    ENSP00000363596.4, OTTHUMP00000015772, ENST00000374472.4, OTTHUMT00000038949
    Conserved Domains (2) summary
    pfam00001
    Location:50299
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:45314
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    23873075..23913327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540629.3XP_011538931.1  cannabinoid receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011538931.1

    UniProtKB/Swiss-Prot
    P34972
    UniProtKB/TrEMBL
    A0A024RAH7
    Conserved Domains (2) summary
    pfam00001
    Location:50299
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:45314
    7tm_4; Olfactory receptor
  2. XM_017000261.2XP_016855750.1  cannabinoid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    P34972
    UniProtKB/TrEMBL
    A0A024RAH7
    Conserved Domains (2) summary
    pfam00001
    Location:50299
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:45314
    7tm_4; Olfactory receptor
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