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KLHDC9 kelch domain containing 9 [ Homo sapiens (human) ]

Gene ID: 126823, updated on 11-Jun-2021

Summary

Official Symbol
KLHDC9provided by HGNC
Official Full Name
kelch domain containing 9provided by HGNC
Primary source
HGNC:HGNC:28489
See related
Ensembl:ENSG00000162755 MIM:617375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KARCA1
Expression
Broad expression in testis (RPKM 19.7), kidney (RPKM 4.9) and 14 other tissues See more
Orthologs
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Genomic context

See KLHDC9 in Genome Data Viewer
Location:
1q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161098361..161100346)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161068151..161070136)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 30 Neighboring gene nectin cell adhesion molecule 4 Neighboring gene NECTIN4 antisense RNA 1 Neighboring gene prefoldin subunit 2 Neighboring gene nitrilase 1 Neighboring gene death effector domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33338

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
kelch domain-containing protein 9
Names
kelch/ankyrin repeat-containing cyclin A1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007255.3NP_001007256.1  kelch domain-containing protein 9 isoform b

    See identical proteins and their annotated locations for NP_001007256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL591806, AY601914, BC066896, BG718418
    Consensus CDS
    CCDS41425.1
    UniProtKB/Swiss-Prot
    Q8NEP7
    Related
    ENSP00000376030.2, ENST00000392192.6
    Conserved Domains (2) summary
    PLN02153
    Location:11164
    PLN02153; epithiospecifier protein
    sd00038
    Location:2876
    Kelch; KELCH repeat [structural motif]
  2. NM_152366.5NP_689579.3  kelch domain-containing protein 9 isoform a

    See identical proteins and their annotated locations for NP_689579.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL591806, BC022077, BC066896, BG718418
    Consensus CDS
    CCDS30919.1
    UniProtKB/Swiss-Prot
    Q8NEP7
    Related
    ENSP00000356990.4, ENST00000368011.9
    Conserved Domains (3) summary
    sd00038
    Location:2876
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:78118
    Kelch_1; Kelch motif
    pfam13415
    Location:3785
    Kelch_3; Galactose oxidase, central domain

RNA

  1. NR_033385.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BC022077, BI549017, BP379202, BQ638407, BU173744
    Related
    ENST00000490724.6
  2. NR_033386.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BC022077, BI549017, BP379202, BU173744

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161098361..161100346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007256.1: Suppressed sequence

    Description
    NM_001007256.1: This RefSeq was permanently suppressed because currently there is insufficient support for the protein.
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