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WDR63 WD repeat domain 63 [ Homo sapiens (human) ]

Gene ID: 126820, updated on 21-Dec-2019

Summary

Official Symbol
WDR63provided by HGNC
Official Full Name
WD repeat domain 63provided by HGNC
Primary source
HGNC:HGNC:30711
See related
Ensembl:ENSG00000162643 MIM:617968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIC3; NYD-SP29
Expression
Biased expression in testis (RPKM 10.4), adrenal (RPKM 9.4) and 2 other tissues See more
Orthologs

Genomic context

See WDR63 in Genome Data Viewer
Location:
1p22.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (85062298..85133138)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (85527993..85598821)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mucolipin 2 Neighboring gene mucolipin 3 Neighboring gene protein GVQW1-like Neighboring gene microRNA 4423 Neighboring gene synapse defective Rho GTPase homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30067, RP11-507C22.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 63
Names
testicular tissue protein Li 225
testis development protein NYD-SP29 (NYD-SP29)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288563.1NP_001275492.1  WD repeat-containing protein 63 isoform 2

    See identical proteins and their annotated locations for NP_001275492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK054629, BX648851, DB075669, DB085334
    Consensus CDS
    CCDS72818.1
    UniProtKB/Swiss-Prot
    Q8IWG1
    Related
    ENSP00000317463.8, ENST00000326813.12
    Conserved Domains (2) summary
    COG2319
    Location:331754
    WD40; WD40 repeat [General function prediction only]
    cl20817
    Location:780834
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_145172.5NP_660155.2  WD repeat-containing protein 63 isoform 1

    See identical proteins and their annotated locations for NP_660155.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC040265, DB075669
    Consensus CDS
    CCDS702.1
    UniProtKB/Swiss-Prot
    Q8IWG1
    UniProtKB/TrEMBL
    A0A140VJZ8
    Related
    ENSP00000294664.6, ENST00000294664.11
    Conserved Domains (1) summary
    COG2319
    Location:370793
    WD40; WD40 repeat [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    85062298..85133138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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