Format

Send to:

Choose Destination

DNAI3 dynein axonemal intermediate chain 3 [ Homo sapiens (human) ]

Gene ID: 126820, updated on 23-Nov-2021

Summary

Official Symbol
DNAI3provided by HGNC
Official Full Name
dynein axonemal intermediate chain 3provided by HGNC
Primary source
HGNC:HGNC:30711
See related
Ensembl:ENSG00000162643 MIM:617968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIC3; WDR63; NYD-SP29
Expression
Biased expression in testis (RPKM 10.4), adrenal (RPKM 9.4) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DNAI3 in Genome Data Viewer
Location:
1p22.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (85062327..85133138)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (85528010..85598821)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13288 Neighboring gene mucolipin TRP cation channel 2 Neighboring gene mucolipin TRP cation channel 3 Neighboring gene protein GVQW1-like Neighboring gene microRNA 4423 Neighboring gene synapse defective Rho GTPase homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30067, RP11-507C22.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of axonemal dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dynein axonemal intermediate chain 3
Names
WD repeat domain 63
WD repeat-containing protein 63
dynein intermediate chain 3, axonemal
testicular tissue protein Li 225
testis development protein NYD-SP29 (NYD-SP29)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288563.2NP_001275492.1  dynein axonemal intermediate chain 3 isoform 2

    See identical proteins and their annotated locations for NP_001275492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK054629, BX648851, DB075669
    Consensus CDS
    CCDS72818.1
    UniProtKB/Swiss-Prot
    Q8IWG1
    Related
    ENSP00000317463.8, ENST00000326813.12
    Conserved Domains (2) summary
    COG2319
    Location:331754
    WD40; WD40 repeat [General function prediction only]
    cl20817
    Location:780834
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_145172.5NP_660155.2  dynein axonemal intermediate chain 3 isoform 1

    See identical proteins and their annotated locations for NP_660155.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC040265, DB075669
    Consensus CDS
    CCDS702.1
    UniProtKB/Swiss-Prot
    Q8IWG1
    UniProtKB/TrEMBL
    A0A140VJZ8
    Related
    ENSP00000294664.6, ENST00000294664.11
    Conserved Domains (1) summary
    COG2319
    Location:370793
    WD40; WD40 repeat [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    85062327..85133138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center