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DNAI3 dynein axonemal intermediate chain 3 [ Homo sapiens (human) ]

Gene ID: 126820, updated on 3-May-2025
Official Symbol
DNAI3provided by HGNC
Official Full Name
dynein axonemal intermediate chain 3provided by HGNC
Primary source
HGNC:HGNC:30711
See related
Ensembl:ENSG00000162643 MIM:617968; AllianceGenome:HGNC:30711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIC3; WDR63; NYD-SP29
Summary
Enables Arp2/3 complex binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation and negative regulation of cell migration. Located in cytoplasm. [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in testis (RPKM 10.4), adrenal (RPKM 9.4) and 2 other tissues See more
Orthologs
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See DNAI3 in Genome Data Viewer
Location:
1p22.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (85062327..85133138)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (84902959..84973727)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (85528010..85598821)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13288 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1260 Neighboring gene mucolipin TRP cation channel 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:85463659-85464530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1265 Neighboring gene mucolipin TRP cation channel 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1029 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:85527645-85528145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1266 Neighboring gene microRNA 4423 Neighboring gene NANOG hESC enhancer GRCh37_chr1:85618513-85619014 Neighboring gene synapse defective Rho GTPase homolog 2 Neighboring gene uncharacterized LOC124904207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:85665814-85666425

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ30067, RP11-507C22.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of axonemal dynein complex IEA
Inferred from Electronic Annotation
more info
 
part_of axonemal dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
dynein axonemal intermediate chain 3
Names
WD repeat domain 63
WD repeat-containing protein 63
dynein intermediate chain 3, axonemal
testicular tissue protein Li 225
testis development protein NYD-SP29 (NYD-SP29)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288563.2NP_001275492.1  dynein axonemal intermediate chain 3 isoform 2

    See identical proteins and their annotated locations for NP_001275492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK054629, BX648851, DB075669
    Consensus CDS
    CCDS72818.1
    UniProtKB/Swiss-Prot
    Q8IWG1
    Related
    ENSP00000317463.8, ENST00000326813.12
    Conserved Domains (2) summary
    COG2319
    Location:331754
    WD40; WD40 repeat [General function prediction only]
    cl20817
    Location:780834
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_145172.5NP_660155.2  dynein axonemal intermediate chain 3 isoform 1

    See identical proteins and their annotated locations for NP_660155.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC040265, DB075669
    Consensus CDS
    CCDS702.1
    UniProtKB/Swiss-Prot
    A8K988, Q8IWG1, Q96L72, Q96NU4
    UniProtKB/TrEMBL
    A0A140VJZ8
    Related
    ENSP00000294664.6, ENST00000294664.11
    Conserved Domains (1) summary
    COG2319
    Location:370793
    WD40; WD40 repeat [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    85062327..85133138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444741.1XP_047300697.1  dynein axonemal intermediate chain 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    84902959..84973727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334256.1XP_054190231.1  dynein axonemal intermediate chain 3 isoform X1