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LRRC38 leucine rich repeat containing 38 [ Homo sapiens (human) ]

Gene ID: 126755, updated on 22-Sep-2022

Summary

Official Symbol
LRRC38provided by HGNC
Official Full Name
leucine rich repeat containing 38provided by HGNC
Primary source
HGNC:HGNC:27005
See related
Ensembl:ENSG00000162494 MIM:615212; AllianceGenome:HGNC:27005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables potassium channel activator activity and transmembrane transporter binding activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 10.5) and prostate (RPKM 0.5) See more
Orthologs
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Genomic context

See LRRC38 in Genome Data Viewer
Location:
1p36.21
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (13474973..13514003, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12916882..12955917, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (13801441..13840498, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRAME family member 17 Neighboring gene PRAME family member 20 Neighboring gene uncharacterized LOC102724856 Neighboring gene uncharacterized LOC107984918 Neighboring gene bromodomain and WD repeat domain containing 1 pseudogene 1 Neighboring gene podoplanin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium channel activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing protein 38
Names
BK channel auxiliary gamma subunit LRRC38
BK channel auxilliary gamma subunit LRRC38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010847.2NP_001010847.1  leucine-rich repeat-containing protein 38 precursor

    See identical proteins and their annotated locations for NP_001010847.1

    Status: VALIDATED

    Source sequence(s)
    AC243961, AL354712, BC016048
    Consensus CDS
    CCDS53269.1
    UniProtKB/Swiss-Prot
    Q5VT99, Q96B32
    Related
    ENSP00000365253.3, ENST00000376085.4
    Conserved Domains (6) summary
    smart00013
    Location:2758
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:45165
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:5881
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3856
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:58116
    LRR_8; Leucine rich repeat
    cl15307
    Location:186237
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    13474973..13514003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444690.1XP_047300646.1  leucine-rich repeat-containing protein 38 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    12916882..12955917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)