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CCSAP centriole, cilia and spindle associated protein [ Homo sapiens (human) ]

Gene ID: 126731, updated on 26-Oct-2022

Summary

Official Symbol
CCSAPprovided by HGNC
Official Full Name
centriole, cilia and spindle associated proteinprovided by HGNC
Primary source
HGNC:HGNC:29578
See related
Ensembl:ENSG00000154429 MIM:616762; AllianceGenome:HGNC:29578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSAP; C1orf96
Summary
Enables microtubule binding activity. Involved in mitotic spindle microtubule depolymerization and regulation of mitotic spindle assembly. Located in axon; ciliary transition zone; and cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 20.5), placenta (RPKM 8.3) and 20 other tissues See more
Orthologs
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Genomic context

See CCSAP in Genome Data Viewer
Location:
1q42.13
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (229321015..229343047, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (228699674..228721751, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (229456762..229478794, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723935 Neighboring gene uncharacterized LOC124904540 Neighboring gene RAB4A antisense RNA 1 Neighboring gene RAB4A, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 13048 Neighboring gene RNA, U6 small nuclear 180, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37296, FLJ41471

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic spindle microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cilium beat frequency involved in ciliary motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle astral microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centriole, cilia and spindle-associated protein
Names
centriole and spindle-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410936.1NP_001397865.1  centriole, cilia and spindle-associated protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL117350, KF455154
    Consensus CDS
    CCDS91172.1
  2. NM_145257.5NP_660300.3  centriole, cilia and spindle-associated protein isoform 1

    See identical proteins and their annotated locations for NP_660300.3

    Status: VALIDATED

    Source sequence(s)
    AL117350, BC015419, BC071609, KF455154
    Consensus CDS
    CCDS1577.1
    UniProtKB/Swiss-Prot
    Q6IQ19, Q96BM2
    Related
    ENSP00000284617.2, ENST00000284617.7
    Conserved Domains (1) summary
    pfam15748
    Location:7269
    CCSAP; Centriole, cilia and spindle-associated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    229321015..229343047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444687.1XP_047300643.1  centriole, cilia and spindle-associated protein isoform X1

    Related
    ENSP00000355647.1, ENST00000366686.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    228699674..228721751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)