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GABPB2 GA binding protein transcription factor subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 126626, updated on 9-Jun-2025
Official Symbol
GABPB2provided by HGNC
Official Full Name
GA binding protein transcription factor subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:28441
See related
Ensembl:ENSG00000143458 AllianceGenome:HGNC:28441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GABPB-2
Summary
Enables transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Annotation information
Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. The gene on Hsa1q was named GABPB2 and the gene on Hsa15q was named GABPB1. [24 Sep 2008]
Expression
Ubiquitous expression in testis (RPKM 4.7), ovary (RPKM 3.2) and 25 other tissues See more
Orthologs
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See GABPB2 in Genome Data Viewer
Location:
1q21.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151070761..151125542)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150194444..150249243)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151043237..151098018)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 56 Neighboring gene CDC42 small effector 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1310 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:151032419-151033010 Neighboring gene MLLT11 transcription factor 7 cofactor Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151042752-151043686 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151043687-151044621 Neighboring gene ribosomal protein S29 pseudogene 29 Neighboring gene uncharacterized LOC124904418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151104130-151104914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1313 Neighboring gene semaphorin 6C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1314

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Replication interactions

Interaction Pubs
Knockdown of GA binding protein transcription factor, beta subunit 2 (GABPB2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC29891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
GA-binding protein subunit beta-2
Names
GA binding protein transcription factor beta subunit 2
GABP subunit beta-2
NP_001310835.1
NP_001310836.1
NP_001310837.1
NP_001310838.1
NP_001310839.1
NP_001310840.1
NP_001310841.1
NP_001310842.1
NP_653219.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323906.2NP_001310835.1  GA-binding protein subunit beta-2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    UniProtKB/TrEMBL
    B2R924
  2. NM_001323907.2NP_001310836.1  GA-binding protein subunit beta-2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
  3. NM_001323908.2NP_001310837.1  GA-binding protein subunit beta-2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    Consensus CDS
    CCDS983.1
    UniProtKB/Swiss-Prot
    B1AVJ8, D3DV14, Q8NAR5, Q8TAK5
    UniProtKB/TrEMBL
    B2R924
    Conserved Domains (2) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
  4. NM_001323909.2NP_001310838.1  GA-binding protein subunit beta-2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    Consensus CDS
    CCDS81373.1
    UniProtKB/TrEMBL
    B2R924, Q5SZG2
    Related
    ENSP00000357912.1, ENST00000368916.1
    Conserved Domains (4) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:42132
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1058
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
  5. NM_001323910.2NP_001310839.1  GA-binding protein subunit beta-2 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    UniProtKB/TrEMBL
    B2R924
    Conserved Domains (5) summary
    cd00204
    Location:54172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:58148
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1074
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:5484
    ANK; ANK repeat [structural motif]
    cl03075
    Location:349406
    GrpE; nucleotide exchange factor GrpE
  6. NM_001323911.2NP_001310840.1  GA-binding protein subunit beta-2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    UniProtKB/TrEMBL
    B2R924
  7. NM_001323912.2NP_001310841.1  GA-binding protein subunit beta-2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
  8. NM_001323913.2NP_001310842.1  GA-binding protein subunit beta-2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
  9. NM_144618.3NP_653219.1  GA-binding protein subunit beta-2 isoform a

    See identical proteins and their annotated locations for NP_653219.1

    Status: VALIDATED

    Source sequence(s)
    AL592424, BC027033
    Consensus CDS
    CCDS983.1
    UniProtKB/Swiss-Prot
    B1AVJ8, D3DV14, Q8NAR5, Q8TAK5
    UniProtKB/TrEMBL
    B2R924
    Related
    ENSP00000357914.3, ENST00000368918.8
    Conserved Domains (2) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151070761..151125542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    150194444..150249243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)