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GABPB2 GA binding protein transcription factor subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 126626, updated on 3-May-2020

Summary

Official Symbol
GABPB2provided by HGNC
Official Full Name
GA binding protein transcription factor subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:28441
See related
Ensembl:ENSG00000143458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GABPB-2
Annotation information
Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. The gene on Hsa1q was named GABPB2 and the gene on Hsa15q was named GABPB1. [24 Sep 2008]
Expression
Ubiquitous expression in testis (RPKM 4.7), ovary (RPKM 3.2) and 25 other tissues See more
Orthologs

Genomic context

See GABPB2 in Genome Data Viewer
Location:
1q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151070180..151125542)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151042784..151091007)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 56 Neighboring gene CDC42 small effector 1 Neighboring gene MLLT11 transcription factor 7 cofactor Neighboring gene ribosomal protein S29 pseudogene 29 Neighboring gene semaphorin 6C Neighboring gene TNFAIP8L2-SCNM1 readthrough Neighboring gene LysM domain containing 1 Neighboring gene TNF alpha induced protein 8 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of GA binding protein transcription factor, beta subunit 2 (GABPB2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GA-binding protein subunit beta-2
Names
GA binding protein transcription factor beta subunit 2
GABP subunit beta-2
NP_001310835.1
NP_001310836.1
NP_001310837.1
NP_001310838.1
NP_001310839.1
NP_001310840.1
NP_001310841.1
NP_001310842.1
NP_653219.1
XP_016855735.1
XP_016855736.1
XP_016855738.1
XP_016855739.1
XP_016855741.1
XP_016855742.1
XP_016855743.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323906.2NP_001310835.1  GA-binding protein subunit beta-2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
  2. NM_001323907.2NP_001310836.1  GA-binding protein subunit beta-2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
  3. NM_001323908.2NP_001310837.1  GA-binding protein subunit beta-2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    Consensus CDS
    CCDS983.1
    UniProtKB/Swiss-Prot
    Q8TAK5
    Conserved Domains (2) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
  4. NM_001323909.2NP_001310838.1  GA-binding protein subunit beta-2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    Consensus CDS
    CCDS81373.1
    UniProtKB/TrEMBL
    Q5SZG2
    Related
    ENSP00000357912.1, ENST00000368916.1
    Conserved Domains (4) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:42132
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1058
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
  5. NM_001323910.2NP_001310839.1  GA-binding protein subunit beta-2 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    Conserved Domains (5) summary
    cd00204
    Location:54172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:58148
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1074
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:5484
    ANK; ANK repeat [structural motif]
    cl03075
    Location:349406
    GrpE; nucleotide exchange factor GrpE
  6. NM_001323911.2NP_001310840.1  GA-binding protein subunit beta-2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
  7. NM_001323912.2NP_001310841.1  GA-binding protein subunit beta-2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
  8. NM_001323913.2NP_001310842.1  GA-binding protein subunit beta-2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
  9. NM_144618.3NP_653219.1  GA-binding protein subunit beta-2 isoform a

    See identical proteins and their annotated locations for NP_653219.1

    Status: VALIDATED

    Source sequence(s)
    AL592424, BC027033
    Consensus CDS
    CCDS983.1
    UniProtKB/Swiss-Prot
    Q8TAK5
    Related
    ENSP00000357914.3, ENST00000368918.8
    Conserved Domains (2) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151070180..151125542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000247.2XP_016855736.1  GA-binding protein subunit beta-2 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:54172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:58148
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1074
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:5484
    ANK; ANK repeat [structural motif]
    cl03075
    Location:349406
    GrpE; nucleotide exchange factor GrpE
  2. XM_017000246.2XP_016855735.1  GA-binding protein subunit beta-2 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:54172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:58148
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1074
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:5484
    ANK; ANK repeat [structural motif]
    cl03075
    Location:349406
    GrpE; nucleotide exchange factor GrpE
  3. XM_017000249.2XP_016855738.1  GA-binding protein subunit beta-2 isoform X2

    UniProtKB/Swiss-Prot
    Q8TAK5
    Conserved Domains (2) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
  4. XM_017000254.2XP_016855743.1  GA-binding protein subunit beta-2 isoform X6

    Conserved Domains (4) summary
    cd00204
    Location:34156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:42132
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1058
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:3868
    ANK; ANK repeat [structural motif]
  5. XM_017000252.2XP_016855741.1  GA-binding protein subunit beta-2 isoform X4

  6. XM_017000253.2XP_016855742.1  GA-binding protein subunit beta-2 isoform X5

  7. XM_017000250.2XP_016855739.1  GA-binding protein subunit beta-2 isoform X3

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