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PLK5 polo like kinase 5 (inactive) [ Homo sapiens (human) ]

Gene ID: 126520, updated on 13-Mar-2020

Summary

Official Symbol
PLK5provided by HGNC
Official Full Name
polo like kinase 5 (inactive)provided by HGNC
Primary source
HGNC:HGNC:27001
See related
Ensembl:ENSG00000185988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLK-5; PLK5P; SgK384ps
Expression
Biased expression in testis (RPKM 2.5), endometrium (RPKM 1.6) and 3 other tissues See more
Orthologs

Genomic context

See PLK5 in Genome Data Viewer
Location:
19p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1524077..1536046)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1524073..1535455)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ADAMTS like 5 Neighboring gene uncharacterized LOC107985337 Neighboring gene CRISPRi-validated cis-regulatory element chr19.367 Neighboring gene mex-3 RNA binding family member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Clone Names

  • MGC118807, MGC118808

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to tumor cell IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inactive serine/threonine-protein kinase PLK5
Names
polo-like kinase 5, pseudogene
NP_001230008.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243079.2NP_001230008.1  inactive serine/threonine-protein kinase PLK5

    See identical proteins and their annotated locations for NP_001230008.1

    Status: VALIDATED

    Source sequence(s)
    AC027307, AI651075, AK054808, BC100791
    Consensus CDS
    CCDS59328.1
    UniProtKB/Swiss-Prot
    Q496M5
    Related
    ENSP00000468376.1, ENST00000454744.7
    Conserved Domains (3) summary
    cd13118
    Location:200275
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl02916
    Location:255336
    POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases
    cl21453
    Location:165
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1524077..1536046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001011716.1: Suppressed sequence

    Description
    NM_001011716.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
  2. NR_026557.1: Suppressed sequence

    Description
    NR_026557.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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