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LRRC25 leucine rich repeat containing 25 [ Homo sapiens (human) ]

Gene ID: 126364, updated on 1-Aug-2020

Summary

Official Symbol
LRRC25provided by HGNC
Official Full Name
leucine rich repeat containing 25provided by HGNC
Primary source
HGNC:HGNC:29806
See related
Ensembl:ENSG00000175489 MIM:607518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAPA
Expression
Broad expression in spleen (RPKM 16.6), bone marrow (RPKM 11.9) and 16 other tissues See more
Orthologs

Genomic context

See LRRC25 in Genome Data Viewer
Location:
19p13.11
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18391137..18397645, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18501947..18508428, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10546 Neighboring gene growth differentiation factor 15 Neighboring gene microRNA 3189 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2899 Neighboring gene single stranded DNA binding protein 4 Neighboring gene inositol-3-phosphate synthase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 25
Names
monocyte and plasmacytoid activated molecule
monocyte and plasmacytoid-activated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145256.3NP_660299.2  leucine-rich repeat-containing protein 25 precursor

    See identical proteins and their annotated locations for NP_660299.2

    Status: VALIDATED

    Source sequence(s)
    AC008397, AJ422148, AK095435, AY358151, BC033825, BI910095
    Consensus CDS
    CCDS12377.1
    UniProtKB/Swiss-Prot
    Q8N386
    Related
    ENSP00000340983.2, ENST00000339007.4
    Conserved Domains (3) summary
    sd00031
    Location:6386
    LRR_1; leucine-rich repeat [structural motif]
    pfam11770
    Location:168303
    GAPT; GRB2-binding adapter (GAPT)
    pfam12799
    Location:62102
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18391137..18397645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259739.4XP_005259796.1  leucine-rich repeat-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_005259796.1

    UniProtKB/Swiss-Prot
    Q8N386
    Related
    ENSP00000472290.1, ENST00000595840.1
    Conserved Domains (3) summary
    sd00031
    Location:6386
    LRR_1; leucine-rich repeat [structural motif]
    pfam11770
    Location:168303
    GAPT; GRB2-binding adapter (GAPT)
    pfam12799
    Location:62102
    LRR_4; Leucine Rich repeats (2 copies)

RNA

  1. XR_001753602.2 RNA Sequence

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