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MISP mitotic spindle positioning [ Homo sapiens (human) ]

Gene ID: 126353, updated on 1-Aug-2020

Summary

Official Symbol
MISPprovided by HGNC
Official Full Name
mitotic spindle positioningprovided by HGNC
Primary source
HGNC:HGNC:27000
See related
Ensembl:ENSG00000099812 MIM:615289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MISP1; C19orf21
Summary
The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Biased expression in small intestine (RPKM 92.0), duodenum (RPKM 77.1) and 6 other tissues See more
Orthologs

Genomic context

See MISP in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (748413..764318)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (750910..764318)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene serine protease 57 Neighboring gene ribosomal protein S2 pseudogene 52 Neighboring gene paralemmin Neighboring gene uncharacterized LOC101928450 Neighboring gene long intergenic non-protein coding RNA 1836

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates MISP (C19orf21) in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686H18209

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
organelle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin filament IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with cortical actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
focal adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with focal adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
colocalizes_with mitotic spindle astral microtubule end IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
spindle pole centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
mitotic interactor and substrate of PLK1
Names
caprice
mitotic interactor and substrate of Plk1
mitotic spindle positioning protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173481.4NP_775752.1  mitotic interactor and substrate of PLK1

    See identical proteins and their annotated locations for NP_775752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AC004030, BC052236, HY163020
    Consensus CDS
    CCDS12042.1
    UniProtKB/Swiss-Prot
    Q8IVT2
    Related
    ENSP00000215582.4, ENST00000215582.8
    Conserved Domains (1) summary
    pfam15304
    Location:325674
    AKAP2_C; A-kinase anchor protein 2 C-terminus

RNA

  1. NR_135168.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC004030, BC052236, HY163020, HY173833

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    748413..764318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527685.2XP_011525987.1  mitotic interactor and substrate of PLK1 isoform X1

    See identical proteins and their annotated locations for XP_011525987.1

    UniProtKB/Swiss-Prot
    Q8IVT2
    Conserved Domains (1) summary
    pfam15304
    Location:325674
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  2. XM_011527686.2XP_011525988.1  mitotic interactor and substrate of PLK1 isoform X1

    See identical proteins and their annotated locations for XP_011525988.1

    UniProtKB/Swiss-Prot
    Q8IVT2
    Conserved Domains (1) summary
    pfam15304
    Location:325674
    AKAP2_C; A-kinase anchor protein 2 C-terminus
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