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MOB3A MOB kinase activator 3A [ Homo sapiens (human) ]

Gene ID: 126308, updated on 6-Sep-2022

Summary

Official Symbol
MOB3Aprovided by HGNC
Official Full Name
MOB kinase activator 3Aprovided by HGNC
Primary source
HGNC:HGNC:29802
See related
Ensembl:ENSG00000172081 AllianceGenome:HGNC:29802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOB1C; moblak; MOB-LAK; MOBKL2A
Summary
Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 27.0), spleen (RPKM 20.7) and 24 other tissues See more
Orthologs
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Genomic context

See MOB3A in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2071036..2096515, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2044090..2069381, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2071035..2096325, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.488 Neighboring gene CRISPRi-validated cis-regulatory element chr19.489 Neighboring gene IZUMO family member 4 Neighboring gene adaptor related protein complex 3 subunit delta 1 Neighboring gene DOT1 like histone lysine methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MOB kinase activator 3A
Names
MOB LAK
MOB1, Mps One Binder kinase activator-like 2A
mob1 homolog 2A
mps one binder kinase activator-like 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130807.3NP_570719.1  MOB kinase activator 3A

    See identical proteins and their annotated locations for NP_570719.1

    Status: VALIDATED

    Source sequence(s)
    AC005328, AK094732, AK095471, BC015049
    Consensus CDS
    CCDS12081.1
    UniProtKB/Swiss-Prot
    Q8TF69, Q96BX8
    Related
    ENSP00000349575.2, ENST00000357066.8
    Conserved Domains (1) summary
    pfam03637
    Location:36208
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2071036..2096515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527683.4XP_011525985.1  MOB kinase activator 3A isoform X1

    See identical proteins and their annotated locations for XP_011525985.1

    UniProtKB/Swiss-Prot
    Q8TF69, Q96BX8
    Conserved Domains (1) summary
    pfam03637
    Location:36208
    Mob1_phocein; Mob1/phocein family
  2. XM_047438169.1XP_047294125.1  MOB kinase activator 3A isoform X1

    UniProtKB/Swiss-Prot
    Q8TF69

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2044090..2069381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)