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JSRP1 junctional sarcoplasmic reticulum protein 1 [ Homo sapiens (human) ]

Gene ID: 126306, updated on 5-Jan-2022

Summary

Official Symbol
JSRP1provided by HGNC
Official Full Name
junctional sarcoplasmic reticulum protein 1provided by HGNC
Primary source
HGNC:HGNC:24963
See related
Ensembl:ENSG00000167476 MIM:608743
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JP45; JP-45
Summary
The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle. [provided by RefSeq, Jul 2012]
Expression
Biased expression in prostate (RPKM 1.9), stomach (RPKM 0.9) and 12 other tissues See more
Orthologs
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Genomic context

See JSRP1 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2252252..2260813, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2252251..2256416, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene splicing factor 3a subunit 2 Neighboring gene AMH 5' regulatory region Neighboring gene microRNA 4321 Neighboring gene anti-Mullerian hormone Neighboring gene uncharacterized LOC105372240 Neighboring gene ornithine decarboxylase antizyme 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
junctional sarcoplasmic reticulum protein 1
Names
2310032K21Rik
homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45
junctional-face membrane protein of 45 kDa homolog
skeletal muscle sarcoplasmic reticulum protein JP-45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032853.1 RefSeqGene

    Range
    5007..9172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144616.4NP_653217.1  junctional sarcoplasmic reticulum protein 1

    See identical proteins and their annotated locations for NP_653217.1

    Status: REVIEWED

    Source sequence(s)
    AK056978, AW137573, DA897543, DA898560
    Consensus CDS
    CCDS12086.1
    UniProtKB/Swiss-Prot
    Q96MG2
    Related
    ENSP00000300961.4, ENST00000300961.10
    Conserved Domains (2) summary
    pfam15312
    Location:115173
    JSRP; Junctional sarcoplasmic reticulum protein
    cl25751
    Location:199323
    DUF4045; Domain of unknown function (DUF4045)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2252252..2260813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026286.1XP_016881775.1  junctional sarcoplasmic reticulum protein 1 isoform X2

  2. XM_017026285.1XP_016881774.1  junctional sarcoplasmic reticulum protein 1 isoform X1

  3. XM_017026287.1XP_016881776.1  junctional sarcoplasmic reticulum protein 1 isoform X3

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