Format

Send to:

Choose Destination

TMIGD2 transmembrane and immunoglobulin domain containing 2 [ Homo sapiens (human) ]

Gene ID: 126259, updated on 9-Jan-2022

Summary

Official Symbol
TMIGD2provided by HGNC
Official Full Name
transmembrane and immunoglobulin domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28324
See related
Ensembl:ENSG00000167664 MIM:614715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD28H; IGPR1; IGPR-1
Summary
Enables coreceptor activity. Involved in positive regulation of T cell activation; positive regulation of angiogenesis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in lymph node (RPKM 1.8), spleen (RPKM 1.5) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMIGD2 in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4292227..4302439, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4292224..4302428, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene YJU2 splicing factor homolog Neighboring gene Src homology 2 domain containing transforming protein D Neighboring gene fibronectin type III and SPRY domain containing 1 Neighboring gene signal transducing adaptor family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC23244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immunoglobulin production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane and immunoglobulin domain-containing protein 2
Names
CD28 homolog
CD28 homologue
immunoglobulin and proline-rich receptor 1
immunoglobulin-containing and proline-rich receptor 1
transmembrane and immunoglobulin domain-containing protein 2 variant 2
transmembrane and immunoglobulin domain-containing protein 2 variant 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169126.2NP_001162597.1  transmembrane and immunoglobulin domain-containing protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001162597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AY358964, BU629751
    Consensus CDS
    CCDS59334.1
    UniProtKB/Swiss-Prot
    Q96BF3
    Related
    ENSP00000470561.1, ENST00000595645.5
    Conserved Domains (2) summary
    smart00410
    Location:29114
    IG_like; Immunoglobulin like
    cl11960
    Location:27133
    Ig; Immunoglobulin domain
  2. NM_001308232.2NP_001295161.1  transmembrane and immunoglobulin domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001295161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AY358964, BC015655, HQ452865, HY260382
    Consensus CDS
    CCDS77217.1
    UniProtKB/Swiss-Prot
    Q96BF3
    UniProtKB/TrEMBL
    A0A0B4J2A9
    Related
    ENSP00000470494.1, ENST00000600114.5
  3. NM_001395549.1NP_001382478.1  transmembrane and immunoglobulin domain-containing protein 2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008616
    Conserved Domains (1) summary
    cl11960
    Location:36112
    Ig; Immunoglobulin domain
  4. NM_144615.3NP_653216.2  transmembrane and immunoglobulin domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_653216.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008616, BC015655, BU629751
    Consensus CDS
    CCDS12126.1
    UniProtKB/Swiss-Prot
    Q96BF3
    Related
    ENSP00000301272.1, ENST00000301272.6
    Conserved Domains (2) summary
    smart00410
    Location:29114
    IG_like; Immunoglobulin like
    cl11960
    Location:27133
    Ig; Immunoglobulin domain

RNA

  1. NR_172630.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008616
  2. NR_172631.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008616
  3. NR_172632.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008616

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4292227..4302439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026284.1XP_016881773.1  transmembrane and immunoglobulin domain-containing protein 2 isoform X1

Support Center