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ZNF573 zinc finger protein 573 [ Homo sapiens (human) ]

Gene ID: 126231, updated on 11-Jun-2021

Summary

Official Symbol
ZNF573provided by HGNC
Official Full Name
zinc finger protein 573provided by HGNC
Primary source
HGNC:HGNC:26420
See related
Ensembl:ENSG00000189144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 1.0), spleen (RPKM 0.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF573 in Genome Data Viewer
Location:
19q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (37738302..37779586, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38229203..38270226, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene selenoprotein K pseudogene 1 Neighboring gene zinc finger protein 607 Neighboring gene Sharpr-MPRA regulatory region 9873 Neighboring gene IST1 homolog Neighboring gene zinc finger protein 607 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172689.2NP_001166160.1  zinc finger protein 573 isoform 2

    See identical proteins and their annotated locations for NP_001166160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons, includes an additional exon, and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AC016582, AK055483, AK074539, BC042170, DA778380
    Consensus CDS
    CCDS54260.1
    UniProtKB/Swiss-Prot
    Q86YE8
    Conserved Domains (3) summary
    COG5048
    Location:156540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:172197
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001172690.2NP_001166161.1  zinc finger protein 573 isoform 3

    See identical proteins and their annotated locations for NP_001166161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons and uses an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK055483, BC042170, BP274132
    Consensus CDS
    CCDS59381.1
    UniProtKB/Swiss-Prot
    Q86YE8
    Related
    ENSP00000440464.2, ENST00000536220.7
    Conserved Domains (5) summary
    smart00349
    Location:2889
    KRAB; krueppel associated box
    COG5048
    Location:244628
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2867
    KRAB; KRAB box
    pfam13465
    Location:260285
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001172691.2NP_001166162.1  zinc finger protein 573 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate exons, uses an alternate splice site, and uses an upstream start codon, compared to variant 1. The resulting isoform (4) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK055483, BC042170, BG572864, DA778380
    UniProtKB/Swiss-Prot
    Q86YE8
    Conserved Domains (5) summary
    smart00349
    Location:2687
    KRAB; krueppel associated box
    COG5048
    Location:242626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:582602
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2665
    KRAB; KRAB box
    pfam13465
    Location:258283
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001172692.2NP_001166163.1  zinc finger protein 573 isoform 2

    See identical proteins and their annotated locations for NP_001166163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks four alternate exons and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AK055483, BC042170, DA778380, DB121870
    Consensus CDS
    CCDS54260.1
    UniProtKB/Swiss-Prot
    Q86YE8
    Conserved Domains (3) summary
    COG5048
    Location:156540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:172197
    zf-H2C2_2; Zinc-finger double domain
  5. NM_152360.4NP_689573.3  zinc finger protein 573 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK055483, BC064962, DA778380
    Consensus CDS
    CCDS12508.1
    UniProtKB/Swiss-Prot
    Q86YE8
    Related
    ENSP00000340171.4, ENST00000339503.7
    Conserved Domains (4) summary
    COG5048
    Location:186570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:526546
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:202227
    zf-H2C2_2; Zinc-finger double domain
    pfam13900
    Location:634
    GVQW; Putative domain of unknown function

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    37738302..37779586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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