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Cer1 cerberus 1, DAN family BMP antagonist [ Mus musculus (house mouse) ]

Gene ID: 12622, updated on 12-Jun-2018
Official Symbol
Cer1provided by MGI
Official Full Name
cerberus 1, DAN family BMP antagonistprovided by MGI
Primary source
MGI:MGI:1201414
See related
Ensembl:ENSMUSG00000038192 Vega:OTTMUSG00000000410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cerl; Cerl1; Cerr1; cer-1
Expression
Low expression observed in reference dataset See more
Orthologs
See Cer1 in Genome Data Viewer
Location:
4 C3; 4 39.4 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (82881751..82885151, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (82527655..82531055, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11269 Neighboring gene zinc finger, DHHC domain containing 21 Neighboring gene Fras1 related extracellular matrix protein 1 Neighboring gene predicted gene, 33260 Neighboring gene predicted gene, 46887

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by BMP, organism-specific biosystem (from REACTOME)
    Signaling by BMP, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
BMP binding ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
morphogen activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
morphogen activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior axis specification IDA
Inferred from Direct Assay
more info
PubMed 
anterior/posterior axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
anterior/posterior pattern specification IDA
Inferred from Direct Assay
more info
PubMed 
bone mineralization ISO
Inferred from Sequence Orthology
more info
 
cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to BMP stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
 
determination of heart left/right asymmetry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
growth plate cartilage chondrocyte proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
NOT negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of mesoderm development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mesoderm development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
sequestering of BMP in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequestering of BMP in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
sequestering of BMP in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cerberus
Names
cer-l
cerberus 1 homolog
cerberus homolog
cerberus-like protein
cerberus-related protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009887.2NP_034017.1  cerberus precursor

    See identical proteins and their annotated locations for NP_034017.1

    Status: VALIDATED

    Source sequence(s)
    AF031896, AL670958, BC132431
    Consensus CDS
    CCDS18295.1
    UniProtKB/Swiss-Prot
    O55233
    UniProtKB/TrEMBL
    A2ADM9
    Related
    ENSMUSP00000048607.3, OTTMUSP00000000437, ENSMUST00000048430.3, OTTMUST00000000986
    Conserved Domains (1) summary
    pfam03045
    Location:146242
    DAN; DAN domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    82881751..82885151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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