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CNGA4 cyclic nucleotide gated channel subunit alpha 4 [ Homo sapiens (human) ]

Gene ID: 1262, updated on 18-Aug-2020

Summary

Official Symbol
CNGA4provided by HGNC
Official Full Name
cyclic nucleotide gated channel subunit alpha 4provided by HGNC
Primary source
HGNC:HGNC:2152
See related
Ensembl:ENSG00000132259 MIM:609472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA
Summary
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 2.8), lung (RPKM 0.7) and 3 other tissues See more
Orthologs

Genomic context

See CNGA4 in Genome Data Viewer
Location:
11p15.4
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6234713..6245924)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6256724..6267066)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 42 Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene family with sequence similarity 160 member A2 Neighboring gene cholecystokinin B receptor Neighboring gene uncharacterized LOC101927825 Neighboring gene caveolae associated protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC126168, MGC126169

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
Golgi-associated vesicle membrane TAS
Traceable Author Statement
more info
 
ciliary membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclic nucleotide-gated cation channel alpha-4
Names
CNG channel alpha-4
cyclic nucleotide gated channel alpha 4
cyclic nucleotide gated channel beta 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037329.4NP_001032406.1  cyclic nucleotide-gated cation channel alpha-4

    See identical proteins and their annotated locations for NP_001032406.1

    Status: VALIDATED

    Source sequence(s)
    AC022762, AK122736, DB238337
    Consensus CDS
    CCDS31408.1
    UniProtKB/Swiss-Prot
    Q8IV77
    Related
    ENSP00000369268.2, ENST00000379936.3
    Conserved Domains (3) summary
    cd00038
    Location:348464
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:34273
    Ion_trans; Ion transport protein
    pfam16526
    Location:464535
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6234713..6245924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448352.1XP_024304120.1  cyclic nucleotide-gated cation channel alpha-4 isoform X2

    Conserved Domains (3) summary
    cd00038
    Location:312428
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:72237
    Ion_trans; Ion transport protein
    pfam16526
    Location:428499
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  2. XM_024448353.1XP_024304121.1  cyclic nucleotide-gated cation channel alpha-4 isoform X4

    Conserved Domains (3) summary
    cd00038
    Location:308424
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:1233
    Ion_trans; Ion transport protein
    pfam16526
    Location:424495
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  3. XM_017017218.2XP_016872707.1  cyclic nucleotide-gated cation channel alpha-4 isoform X3

  4. XM_017017219.1XP_016872708.1  cyclic nucleotide-gated cation channel alpha-4 isoform X3

  5. XM_017017217.1XP_016872706.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

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